PMID- 22119815
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20111128
IS  - 2066-8279 (Electronic)
IS  - 1220-0522 (Linking)
VI  - 52
IP  - 3 Suppl
DP  - 2011
TI  - Investigation of P213S SELL gene polymorphism in type 2 diabetes mellitus and 
      related end stage renal disease. A case-control study.
PG  - 995-8
AB  - SELL (L-selectin) is a candidate gene for several complex diseases including 
      diabetes mellitus and renal failure. Our aim was to investigate the involvement 
      of P213S SELL gene polymorphism (rs2229569) in type 2 diabetes mellitus (T2DM) 
      and related end stage renal disease (ESRD). Type 2 diabetes mellitus patients 
      without ESRD (n=250) or with ESRD (n=90), ESRD patients without diabetes (n=119) 
      and sex and age matched healthy subjects (n=459) were analyzed in this study. DNA 
      samples from all these subjects were genotyped for the P213S polymorphism by 
      PCR-RFLP technique. Statistical analysis indicated that SELL P213S genotypes and 
      alleles were similar distributed in the patients and control groups (ORSS=0.37, 
      CI 95%: 0.131>0.372>1.06, p=0.05, Yate's correction p=0.09, for T2DM patients 
      without ESRD, ORSS=2.04, CI 95%: 0.365>2.047>1.465, p=0.4, Yate's correction 
      p=0.67, for T2DM patients with ESRD and ORSS=1, CI95%: 0.198>1>5.057, p=1, Yate's 
      correction p=0.67, for non-diabetic with ESRD patients). Also, no significant 
      differences were noticed when we compared the ESRD subjects with diabetes vs. 
      non-diabetic ones (OR=1.798, CI 95%: 0.392>1.798>8.245, p=0.44, Yate's correction 
      p=0.7). No statistically significant results were found in order to sustain the 
      hypothesis of association between SELL gene P213S polymorphism, type 2 diabetes 
      mellitus and end stage renal disease.
FAU - Stavarachi, Monica
AU  - Stavarachi M
AD  - Department of Genetics, University of Bucharest, Romania. monica. 
      stavarachi@gmail.com
FAU - Panduru, N M
AU  - Panduru NM
FAU - Serafinceanu, C
AU  - Serafinceanu C
FAU - Mota, E
AU  - Mota E
FAU - Mota, Maria
AU  - Mota M
FAU - Cimponeriu, D
AU  - Cimponeriu D
FAU - Ion, Daniela Adriana
AU  - Ion DA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Romania
TA  - Rom J Morphol Embryol
JT  - Romanian journal of morphology and embryology = Revue roumaine de morphologie et 
      embryologie
JID - 9112454
RN  - 0 (SELL protein, human)
RN  - 126880-86-2 (L-Selectin)
SB  - IM
MH  - Alleles
MH  - Amino Acid Substitution/genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Kidney Failure, Chronic/*complications/*genetics
MH  - L-Selectin/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
EDAT- 2011/12/14 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - 521311995998 [pii]
PST - ppublish
SO  - Rom J Morphol Embryol. 2011;52(3 Suppl):995-8.