PMID- 22120209
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20111207
IS  - 1478-3975 (Electronic)
IS  - 1478-3967 (Linking)
VI  - 8
IP  - 6
DP  - 2011 Dec
TI  - Tug of war of molecular motors: the effects of uneven load sharing.
PG  - 066010
LID - 10.1088/1478-3975/8/6/066010 [doi]
AB  - We analyze theoretically the problem of cargo transport along microtubules by 
      motors of two species with opposite polarities. We consider two different 
      one-dimensional models previously developed in the literature: a quite widespread 
      model which assumes equal force sharing, here referred to as the mean field model 
      (MFM), and a stochastic model (SM) which considers individual motor-cargo links. 
      We find that in generic situations, the MFM predicts larger cargo mean velocity, 
      smaller mean run time and less frequent reversions than the SM. These phenomena 
      are found to be the consequences of the load sharing assumptions and can be 
      interpreted in terms of the probabilities of the different motility states. We 
      also explore the influence of the viscosity in both models and the role of the 
      stiffness of the motor-cargo links within the SM. Our results show that the mean 
      cargo velocity is independent of the stiffness, while the mean run time decreases 
      with such a parameter. We explore the case of symmetric forward and backward 
      motors considering kinesin-1 parameters, and the problem of transport by 
      kinesin-1 and cytoplasmic dyneins considering two different sets of parameters 
      previously proposed for dyneins.
FAU - Bouzat, Sebastian
AU  - Bouzat S
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas, Centro Atomico 
      Bariloche (CNEA), Argentina. bouzat@cab.cnea.gov.ar
FAU - Falo, Fernando
AU  - Falo F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111125
PL  - England
TA  - Phys Biol
JT  - Physical biology
JID - 101197454
RN  - 0 (Molecular Motor Proteins)
SB  - IM
MH  - Biological Transport
MH  - Microtubules/metabolism
MH  - Models, Biological
MH  - Molecular Motor Proteins/*metabolism
MH  - Stochastic Processes
EDAT- 2011/11/29 06:00
MHDA- 2012/03/28 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
AID - S1478-3975(11)05012-6 [pii]
AID - 10.1088/1478-3975/8/6/066010 [doi]
PST - ppublish
SO  - Phys Biol. 2011 Dec;8(6):066010. doi: 10.1088/1478-3975/8/6/066010. Epub 2011 Nov 
      25.