PMID- 22121090
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20121004
IS  - 1098-2744 (Electronic)
IS  - 0899-1987 (Linking)
VI  - 51 Suppl 1
DP  - 2012 Oct
TI  - Matrix metalloproteinase3 gene promoter polymorphisms and their haplotypes are 
      associated with gastric cancer risk in eastern Indian population.
PG  - E42-53
LID - 10.1002/mc.21837 [doi]
AB  - Single nucleotide polymorphisms (SNPs) of matrix metalloproteinase3 (MMP3) 
      promoter in the development and progression of gastric cancer of whole stomach 
      has never been investigated in any population. We conducted a hospital-based 
      case-control study to explore the MMP3 SNPs and their haplotypes with the risk of 
      gastric cancer for the first time in eastern Indian population. A total of 218 
      gastric cancer patients and 175 healthy controls were genotyped for MMP3-1612 
      5A/6A (rs3025058) by PCR-RFLP and rechecked 10% by DNA sequencing. MMP3-707 A/G 
      (rs522616) and MMP3-375 C/G (rs617819) were genotyped by DNA sequencing among 209 
      patients and 154 controls. MMP3-1612 5A6A genotype (P = 0.026, odds ratio (OR) = 
      1.756, confidence interval (CI) = 1.070-2.883), combined 5A5A and 5A6A genotype 
      (P = 0.015, OR = 1.791, CI = 1.122-2.858) and 5A allele (P = 0.002, OR = 1.75, CI 
      = 1.21-2.53) and; MMP3-707 GG genotype (P = < 0.0001; OR = 9.612; 95% CI = 
      3.403-27.147), combined GG and AG genotype (P = 0.001, OR = 2.201, CI = 
      1.385-3.498) and G allele (P = <0.0001, OR = 2.189, CI = 1.582-3.033) conferred 
      significant risk for gastric cancer development. Also, tobacco addicted 
      individuals with combined 5A5A and 5A6A genotype (P = 0.005, OR = 2.952, CI = 
      1.377-6.327) at -1612 position of MMP3 promoter displayed a higher risk to 
      gastric cancer development. The genotypic combinations of all three MMP3 promoter 
      polymorphisms and their haplotypes with increasing risk allele in a 
      dose-dependent manner showed a potential risk for developing gastric cancer. The 
      analyses suggested that the MMP3-707 G/G and MMP3-1612 5A/6A polymorphisms are 
      potential independent predictors of gastric cancer risk development.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Dey, Sanjib
AU  - Dey S
AD  - Department of Physiology, Drug Development Diagnostic and Biotechnology Division, 
      Indian Institute of Chemical Biology, Kolkata, India.
FAU - Stalin, Sami
AU  - Stalin S
FAU - Gupta, Arnab
AU  - Gupta A
FAU - Saha, Debjit
AU  - Saha D
FAU - Kesh, Kousik
AU  - Kesh K
FAU - Swarnakar, Snehasikta
AU  - Swarnakar S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111128
PL  - United States
TA  - Mol Carcinog
JT  - Molecular carcinogenesis
JID - 8811105
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Base Sequence
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Haplotypes/genetics
MH  - Humans
MH  - India
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Stomach Neoplasms/etiology/*genetics/pathology
EDAT- 2011/11/29 06:00
MHDA- 2013/01/23 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/02/16 00:00 [received]
PHST- 2011/10/18 00:00 [revised]
PHST- 2011/10/19 00:00 [accepted]
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - 10.1002/mc.21837 [doi]
PST - ppublish
SO  - Mol Carcinog. 2012 Oct;51 Suppl 1:E42-53. doi: 10.1002/mc.21837. Epub 2011 Nov 
      28.