PMID- 22121592
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20190715
IS  - 1533-4880 (Print)
IS  - 1533-4880 (Linking)
VI  - 11
IP  - 7
DP  - 2011 Jul
TI  - Development of a biodegradable sirolimus-eluting stent coated by ultrasonic 
      atomizing spray.
PG  - 5689-97
AB  - In this study, poly(D,L lactic-co-glycolic acid) (PLGA) was used as a drug 
      carrier to generate two types of stents loaded with different concentrations of 
      sirolimus. These stents were prepared by ultrasonic atomizing spray coating. 
      Ultrasonic atomizing spray nozzle uses a low-pressure air/gas to produce a soft, 
      highly focused beam of small spray drops. An isolated hypotube delivers liquid to 
      the nozzle's atomizing surface while air/gas, delivered through the nozzle 
      orifice at a fixed low pressure, shapes the atomized drops into a very precise, 
      targeted spray. The stent was moved both in the traverse direction and rotated 
      during the spraying process. The morphology of the sirolimus-eluting stents was 
      examined by scanning electron microscopy (SEM) which indicated that the coating 
      was very smooth and uniform. The coating was found to have the ability to 
      withstand the compressive and tensile strains imparted without cracking during 
      the stent inflation process. Release profile of sirolimus was measured by high 
      performance liquid chromatography (HPLC). The release behavior of sirolimus from 
      the stent surface had a two phase release profile with a burst release period of 
      about 2 days, followed by a sustained and slow release phase. The mass loss 
      behavior of PLGA appeared linear throughout most of the degradation period. At 28 
      days, neointimal formation was found to be significantly decreased for both 
      sirolimus-eluting stents as compared to bare-metal stents (BMS). Assessment of 
      vascular healing revealed an absence of increased inflammation in both 
      sirolimus-eluting stents. Inflammation is commonly observed in drug-eluting 
      stents (DES) with nonbiodegradable polymeric coatings. Taking these results into 
      account, these novel sirolimus-eluting stents may be good candidates to resolve 
      in-stent restenosis.
FAU - Kim, Soon-Joong
AU  - Kim SJ
AD  - Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, 
      School of Dentistry, Kyung Hee University, Seoul 130-701, Korea.
FAU - Park, Jae-Geun
AU  - Park JG
FAU - Kim, Jung Ho
AU  - Kim JH
FAU - Heo, Jung Sun
AU  - Heo JS
FAU - Choi, Jeong-Woo
AU  - Choi JW
FAU - Jang, Yang-Soo
AU  - Jang YS
FAU - Yoon, Junghan
AU  - Yoon J
FAU - Lee, Seung Jin
AU  - Lee SJ
FAU - Kwon, Il Keun
AU  - Kwon IK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nanosci Nanotechnol
JT  - Journal of nanoscience and nanotechnology
JID - 101088195
RN  - 0 (Coated Materials, Biocompatible)
RN  - 059QF0KO0R (Water)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - Coated Materials, Biocompatible/chemistry
MH  - Drug Delivery Systems/*instrumentation
MH  - *Drug-Eluting Stents
MH  - Lactic Acid/chemistry
MH  - Materials Testing
MH  - Microscopy, Electron, Scanning
MH  - Nebulizers and Vaporizers
MH  - Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Prosthesis Design
MH  - Sirolimus/*administration & dosage/chemistry/pharmacokinetics
MH  - Swine
MH  - Water
EDAT- 2011/11/30 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.1166/jnn.2011.4496 [doi]
PST - ppublish
SO  - J Nanosci Nanotechnol. 2011 Jul;11(7):5689-97. doi: 10.1166/jnn.2011.4496.