PMID- 22122397
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20191112
IS  - 2212-3911 (Electronic)
IS  - 1574-8863 (Linking)
VI  - 6
IP  - 3
DP  - 2011 Jul
TI  - Hypomagnesaemia/hypokalemia associated with the use of esomeprazole.
PG  - 204-6
AB  - Magnesium homeostasis is essential for many intracellular processes and depends 
      on dynamic interplay of intestinal absorption, exchange with the bone reservoir, 
      and renal excretion. Hypomagnesaemia may arise from various disorders. We review 
      the case of a 59 year-old man whose only complaint was irritability with a 
      routine analysis showing hypomagnesaemia and hypokalemia while using 
      esomeprazole, a proton pump inhibitor (PPI). Fractional magnesium excretion was 
      low, excluding excessive renal loss. Potassium excretion was 80 mEq/24 Hr in the 
      presence of hypokalemia suggesting hypomagnesaemia-induced kaliuresis as its 
      cause. Hypomagnesaemia partially resolved after oral magnesium supplementation. 
      Esomeprazol suppression corrected hypomagnesaemia. A causal relationship with 
      esomeprazol use was supported by the recurrence of hypomagnesaemia after 
      rechallenge. We review the literature on hypomagnesaemia due to the use of proton 
      pump inhibitors. In the past decade our understanding of transcellular magnesium 
      transport was enhanced by the discovery of the magnesium channel, transient 
      receptor potential (TR PM) 6 and 7 and other proteins that play an important role 
      in its transport. In this light we discuss the possible etiology of proton pump 
      inhibitor related hypomagnesaemia/hypokalemia.
FAU - Negri, Armando L
AU  - Negri AL
AD  - Instituto de Investigaciones Metabolicas, Universidad del Salvador, School of 
      Medicine, Buenos Aires, Argentina. secger@idim.com.ar
FAU - Valle, Elisa E Del
AU  - Valle EE
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Saf
JT  - Current drug safety
JID - 101270895
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - I38ZP9992A (Magnesium)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
EIN - Curr Drug Saf. 2013 Feb;8(1):75
MH  - Anti-Ulcer Agents/adverse effects/therapeutic use
MH  - Esomeprazole/*adverse effects/therapeutic use
MH  - Humans
MH  - Hypokalemia/*chemically induced
MH  - Magnesium/*blood/metabolism
MH  - Magnesium Deficiency/chemically induced
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*adverse effects
EDAT- 2011/11/30 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/06/13 00:00 [received]
PHST- 2011/07/07 00:00 [revised]
PHST- 2011/07/12 00:00 [accepted]
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - BSP/CDS/6/3/0204 [pii]
AID - 10.2174/157488611797579320 [doi]
PST - ppublish
SO  - Curr Drug Saf. 2011 Jul;6(3):204-6. doi: 10.2174/157488611797579320.