PMID- 22122790
OWN - NLM
STAT- MEDLINE
DCOM- 20120406
LR  - 20181201
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 22
IP  - 8
DP  - 2011 Dec
TI  - Decrease in interleukin-21 in children suffering with severe atopic dermatitis.
PG  - 869-75
LID - 10.1111/j.1399-3038.2011.01209.x [doi]
AB  - BACKGROUND: Atopic dermatitis (AD) is a kind of eczema with an inflammatory, 
      relapsing, non-contagious, and pruritic skin disorder. It is associated with the 
      local infiltration of T helper type 2 (Th2) cells that secrete interleukin (IL)-4 
      and IL-5. IL-21 is a member of IL-2 family cytokine mainly expressed by activated 
      CD4+ T lymphocytes. Until now, there is no clinical research in the expression of 
      IL-21 in patients with AD. METHODS: We analyzed serum levels of total 
      immunoglobulin E (IgE), allergen-specific IgE, and cytokines IL-4, IL-5, IFN-gamma, 
      IL-17, and IL-21 in AD cases and controls. In addition, cytokine levels in the 
      culture supernatants of peripheral blood mononuclear cells stimulated with 
      anti-CD3 and anti-CD28 Abs, phytohemagglutin (PHA), or pokeweed mitogen (PWM) 
      were measured. We also assessed clinical skin severity by Scoring of Atopic 
      Dermatitis (SCORAD) index. RESULTS: Our results showed that serum total IgE in 
      the case group was significantly higher than that of control group (365.449 +/- 
      52.945 and 39.243 +/- 7.605 IU/ml, respectively). Logistic regression analysis 
      system reveals serum levels of IL-21 and IFN-gamma are significantly correlated. 
      However, IL-21 and IL-4, IL-21 and IL-5, as well as IL-21 and IL-17 showed no 
      correlation. CONCLUSION: A significantly decreased level of IL-21 was observed in 
      children suffering with severe AD compared with controls, suggesting that IL-21 
      may play a role in AD.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Lin, Sheng-Chieh
AU  - Lin SC
AD  - Department of Pediatrics, Shuang Ho Hospital, Taipei Medical University, Taipei, 
      Taiwan.
FAU - Chuang, Ya-Hui
AU  - Chuang YH
FAU - Yang, Yao-Hsu
AU  - Yang YH
FAU - Chiang, Bor-Luen
AU  - Chiang BL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (CD28 Antigens)
RN  - 0 (CD3 Complex)
RN  - 0 (Interleukins)
RN  - 0 (Phytohemagglutinins)
RN  - 0 (Pokeweed Mitogens)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
RN  - MKM3CA6LT1 (interleukin-21)
SB  - IM
MH  - Antibodies, Monoclonal/immunology/metabolism
MH  - CD28 Antigens/immunology
MH  - CD3 Complex/immunology
MH  - Cells, Cultured
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/blood/*immunology/*physiopathology
MH  - Disease Progression
MH  - Down-Regulation
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interferon-gamma/genetics/immunology/*metabolism
MH  - Interleukins/genetics/immunology/*metabolism
MH  - Male
MH  - Phytohemagglutinins/immunology/metabolism
MH  - Pokeweed Mitogens/immunology/metabolism
MH  - Th2 Cells/immunology/*metabolism/pathology
EDAT- 2011/11/30 06:00
MHDA- 2012/04/07 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/04/07 06:00 [medline]
AID - 10.1111/j.1399-3038.2011.01209.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2011 Dec;22(8):869-75. doi: 
      10.1111/j.1399-3038.2011.01209.x.