PMID- 22125456
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20211021
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 11
DP  - 2011
TI  - Human leukocyte antigen class I and II alleles and overall survival in diffuse 
      large B-cell lymphoma and follicular lymphoma.
PG  - 2062-70
LID - 10.1100/2011/373876 [doi]
AB  - Genetic variation in the 6p21 chromosomal region, including human leukocyte 
      antigen (HLA) genes and tumor necrosis factor (TNF), has been linked to both 
      etiology and clinical outcomes of lymphomas. We estimated the effects of HLA 
      class I (A, B, and C), class II DRB1 alleles, and the ancestral haplotype (AH) 
      8.1 (HLAA*01-B*08-DRB1*03-TNF-308A) on overall survival (OS) among patients with 
      diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in a 
      population-based study of non-Hodgkin lymphoma. During a median followup of 89 
      months, 31% (52 of 166) DLBCL and 28% (46 of 165) FL patients died. Using 
      multivariate Cox regression models, we observed statistically significant 
      associations between genetic variants and survival: HLA-Cw*07:01 was associated 
      with poorer OS among DLBCL patients (Hazard ratio [HR] = 1.76, 95% confidence 
      interval [CI] = 1.01-3.05); HLA-A*01:01 was associated with poorer OS (HR = 2.23, 
      95% CI = 1.24-4.01), and HLA-DRB1*13 (HR = 0.12, 95% CI = 0.02-0.90) and HLA-B 
      Bw4 (HR = 0.36, 95% CI = 0.20-0.63) with better OS among FL patients. These 
      results support a role for HLA in the prognosis of DLBCL and FL and represent a 
      promising class of prognostic factors that warrants further evaluation.
FAU - Lu, Yani
AU  - Lu Y
AD  - Division of Cancer Etiology, Department of Population Sciences, Beckman Research 
      Institute, City of Hope, Duarte, CA 91010, USA.
FAU - Abdou, Amr M
AU  - Abdou AM
FAU - Cerhan, James R
AU  - Cerhan JR
FAU - Morton, Lindsay M
AU  - Morton LM
FAU - Severson, Richard K
AU  - Severson RK
FAU - Davis, Scott
AU  - Davis S
FAU - Cozen, Wendy
AU  - Cozen W
FAU - Rothman, Nathaniel
AU  - Rothman N
FAU - Bernstein, Leslie
AU  - Bernstein L
FAU - Chanock, Stephen
AU  - Chanock S
FAU - Hartge, Patricia
AU  - Hartge P
FAU - Wang, Sophia S
AU  - Wang SS
LA  - eng
GR  - N01 PC067010/PC/NCI NIH HHS/United States
GR  - N01 PC067008/PC/NCI NIH HHS/United States
GR  - N01-PC-67009/PC/NCI NIH HHS/United States
GR  - N01 PC065064/PC/NCI NIH HHS/United States
GR  - R01 CA096704/CA/NCI NIH HHS/United States
GR  - R01 CA96704/CA/NCI NIH HHS/United States
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
GR  - N01 PC067009/CN/NCI NIH HHS/United States
GR  - N02-PC-71105/PC/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111101
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
SB  - IM
MH  - *Alleles
MH  - Chromosomes, Human, Pair 6
MH  - Female
MH  - *Genes, MHC Class I
MH  - *Genes, MHC Class II
MH  - Humans
MH  - Lymphoma, Follicular/*genetics/pathology
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Survival Rate
PMC - PMC3217596
OTO - NOTNLM
OT  - diffuse large B-cell lymphoma
OT  - follicular lymphoma
OT  - human leukocyte antigen
OT  - survival
OT  - tumor necrosis factor
EDAT- 2011/11/30 06:00
MHDA- 2012/03/28 06:00
PMCR- 2011/11/01
CRDT- 2011/11/30 06:00
PHST- 2011/07/29 00:00 [received]
PHST- 2011/10/03 00:00 [accepted]
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - 10.1100/2011/373876 [doi]
PST - ppublish
SO  - ScientificWorldJournal. 2011;11:2062-70. doi: 10.1100/2011/373876. Epub 2011 Nov 
      1.