PMID- 22125457
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20211021
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 11
DP  - 2011
TI  - Overlapping, additive and counterregulatory effects of type II and I interferons 
      on myeloid dendritic cell functions.
PG  - 2071-90
LID - 10.1100/2011/873895 [doi]
AB  - Dendritic cells (DCs) are central player in immunity by bridging the innate and 
      adaptive arms of the immune system (IS). Interferons (IFNs) are one of the most 
      important factors that regulate both innate and adaptive immunity too. Thus, the 
      understanding of how type II and I IFNs modulate the immune-regulatory properties 
      of DCs is a central issue in immunology. In this paper, we will address this 
      point in the light of the most recent literature, also highlighting the 
      controversial data reported in the field. According to the wide literature 
      available, type II as well as type I IFNs appear, at the same time, to 
      collaborate, to induce additive effects or overlapping functions, as well as to 
      counterregulate each one's effects on DC biology and, in general, the immune 
      response. The knowledge of these effects has important therapeutic implications 
      in the treatment of infectious/autoimmune diseases and cancer and indicates 
      strategies for using IFNs as vaccine adjuvants and in DC-based immune therapeutic 
      approaches.
FAU - Frasca, Loredana
AU  - Frasca L
AD  - Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto 
      Superiore di Sanita, 00161 Rome, Italy. lfrasca@iss.it
FAU - Lande, Roberto
AU  - Lande R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111101
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
RN  - 0 (Interferon Type I)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Interferon Type I/*physiology
MH  - Interferon-gamma/*physiology
MH  - Myeloid Cells/*immunology
PMC - PMC3221594
OTO - NOTNLM
OT  - IFNs
OT  - cross-regulation
OT  - dendritic cell effector functions
OT  - immune activation
OT  - immune regulation
EDAT- 2011/11/30 06:00
MHDA- 2012/03/28 06:00
PMCR- 2011/11/01
CRDT- 2011/11/30 06:00
PHST- 2011/04/08 00:00 [received]
PHST- 2011/09/27 00:00 [accepted]
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - 10.1100/2011/873895 [doi]
PST - ppublish
SO  - ScientificWorldJournal. 2011;11:2071-90. doi: 10.1100/2011/873895. Epub 2011 Nov 
      1.