PMID- 22127547
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20231213
IS  - 1936-0568 (Electronic)
IS  - 1936-055X (Print)
IS  - 1936-055X (Linking)
VI  - 6
IP  - 2
DP  - 2012 Jun
TI  - Re-evaluating historic cohort of salivary acinic cell carcinoma with new 
      diagnostic tools.
PG  - 166-70
LID - 10.1007/s12105-011-0312-9 [doi]
AB  - Mammary analogue secretory carcinoma (MASC) was recently identified as a distinct 
      salivary gland neoplasm, morphologically resembling intercalated duct cell 
      predominant acinic cell carcinoma (AciCC). To determine how frequently MASC has 
      mimicked an intercalated duct cell predominant AciCC, we reviewed AciCC diagnosed 
      from 1956 to 1975. Nine AciCC consecutively diagnosed in that period were 
      identified. Based on morphologic examination, one case diagnosed as AciCC in a 
      male patient in 1960 was re-classified as MASC [confirmed by fluorescence in situ 
      hybridization (FISH) showing ETV6 translocation]. Another case diagnosed as AciCC 
      of the palate in a female patient in 1975 was re-classified as mucoepidermoid 
      carcinoma (based on the lack of acinar differentiation, presence of mucous cells, 
      and confirmed by FISH showing MAML2 translocation). In this proof-of-principle 
      study, we show that 1 in 9 cases historically designated as AciCC represents a 
      MASC. "Intercalated duct cell predominant AciCC", especially among male patients, 
      most likely represent examples of MASC. For anatomic sites outside of the parotid 
      glands, broader differential diagnoses should be considered before accepting 
      morphologic variants of AciCC as the final diagnosis.
FAU - Lei, Yu
AU  - Lei Y
AD  - Department of Diagnostic Sciences, School of Dental Medicine, University of 
      Pittsburgh Medical Center, 3501 Terrace Street, Pittsburgh, PA 15261, USA. 
      leiy@upmc.edu
FAU - Chiosea, Simion I
AU  - Chiosea SI
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20111130
PL  - United States
TA  - Head Neck Pathol
JT  - Head and neck pathology
JID - 101304010
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MAML2 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proto-Oncogene Proteins c-ets)
RN  - 0 (Repressor Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adult
MH  - Carcinoma/diagnosis/genetics
MH  - Carcinoma, Acinar Cell/*diagnosis/genetics
MH  - Carcinoma, Mucoepidermoid/diagnosis
MH  - Cohort Studies
MH  - DNA-Binding Proteins/genetics
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Male
MH  - Nuclear Proteins/genetics
MH  - Proto-Oncogene Proteins c-ets/genetics
MH  - Repressor Proteins/genetics
MH  - Salivary Gland Neoplasms/*diagnosis/genetics
MH  - Trans-Activators
MH  - Transcription Factors/genetics
MH  - ETS Translocation Variant 6 Protein
PMC - PMC3370021
EDAT- 2011/12/01 06:00
MHDA- 2012/10/02 06:00
PMCR- 2012/11/30
CRDT- 2011/12/01 06:00
PHST- 2011/09/06 00:00 [received]
PHST- 2011/11/11 00:00 [accepted]
PHST- 2011/12/01 06:00 [entrez]
PHST- 2011/12/01 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
PHST- 2012/11/30 00:00 [pmc-release]
AID - 312 [pii]
AID - 10.1007/s12105-011-0312-9 [doi]
PST - ppublish
SO  - Head Neck Pathol. 2012 Jun;6(2):166-70. doi: 10.1007/s12105-011-0312-9. Epub 2011 
      Nov 30.