PMID- 22127745
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20231105
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 1
IP  - 2
DP  - 2010 Dec
TI  - Dapagliflozin: a sodium glucose cotransporter 2 inhibitor in development for type 
      2 diabetes.
PG  - 45-56
LID - 10.1007/s13300-010-0007-3 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a growing worldwide epidemic. Patients face 
      lifelong therapy to control hyperglycemia and prevent the associated 
      complications. There are many medications, with varying mechanisms, available for 
      the treatment of T2DM, but almost all target the declining insulin sensitivity 
      and secretion that are associated with disease progression. Medications with such 
      insulin-dependent mechanisms of action often lose efficacy over time, and there 
      is increasing interest in the development of new antidiabetes medications that 
      are not dependent upon insulin. One such approach is through the inhibition of 
      renal glucose reuptake. Dapagliflozin, the first of a class of selective sodium 
      glucose cotransporter 2 inhibitors, reduces renal glucose reabsorption and is 
      currently under development for the treatment of T2DM. Here, we review the 
      literature relating to the preclinical and clinical development of dapagliflozin.
FAU - Tahrani, Abd A
AU  - Tahrani AA
AD  - Heart of England NHS Foundation Trust, Birmingham Heartlands Hospital, Bordesley 
      Green East, Birmingham, B9 5SS, UK, a.a.tahrani@bham.ac.uk.
FAU - Barnett, Anthony H
AU  - Barnett AH
LA  - eng
GR  - RTF/01/094/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20110119
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
PMC - PMC3138480
OTO - NOTNLM
OT  - SGLT2
OT  - dapagliflozin
OT  - diabetes
OT  - inhibitor
EDAT- 2011/12/01 06:00
MHDA- 2011/12/01 06:01
CRDT- 2011/12/01 06:00
PHST- 2010/08/04 00:00 [received]
PHST- 2011/12/01 06:00 [entrez]
PHST- 2011/12/01 06:00 [pubmed]
PHST- 2011/12/01 06:01 [medline]
AID - 10.1007/s13300-010-0007-3 [doi]
PST - ppublish
SO  - Diabetes Ther. 2010 Dec;1(2):45-56. doi: 10.1007/s13300-010-0007-3. Epub 2011 Jan 
      19.