PMID- 22128036
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20231105
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 120
IP  - 3
DP  - 2012 Mar
TI  - In utero exposure to maternal tobacco smoke and subsequent obesity, hypertension, 
      and gestational diabetes among women in the MoBa cohort.
PG  - 355-60
LID - 10.1289/ehp.1103789 [doi]
AB  - BACKGROUND: Environmental factors influencing the developmental origins of health 
      and disease need to be identified and investigated. In utero exposure to tobacco 
      smoke has been associated with obesity and a small increase in blood pressure in 
      children; however, whether there is a corresponding increased risk of conditions 
      such as diabetes and hypertension during adulthood remains unclear. OBJECTIVE: 
      Our goal was to assess the association of self-reported in utero exposure to 
      tobacco smoke with the prevalence of obesity, hypertension, type 2 diabetes 
      mellitus (T2DM), and gestational diabetes mellitus (GDM) in women 14-47 years of 
      age. METHODS: We conducted a cross-sectional analysis of the Norwegian Mother and 
      Child Cohort Study, which enrolled pregnant women in Norway from 1999 thorough 
      2008. Exposure to tobacco smoke in utero (yes vs. no) was ascertained on the 
      baseline questionnaire (obtained at ~ 17 weeks' gestation); the outcomes were 
      ascertained from the Medical Birth Registry of Norway and the questionnaire. Our 
      analysis included 74,023 women. RESULTS: Women exposed to tobacco smoke in utero 
      had 1.53 times the odds of obesity [95% confidence interval (CI): 1.45, 1.61] 
      relative to those unexposed, after adjusting for age, education, and personal 
      smoking. After further adjustment for body mass index, the odds ratio for 
      hypertension was 1.68 (95% CI: 1.19, 2.39); for T2DM 1.14 (95% CI: 0.79, 1.65); 
      and for GDM 1.32 (95% CI: 1.10, 1.58) among exposed compared with unexposed. 
      CONCLUSIONS: Exposure to tobacco smoke in utero was associated with obesity, 
      hypertension, and GDM in adult women. The possibility that the associations were 
      attributable to unmeasured confounding cannot be excluded.
FAU - Cupul-Uicab, Lea A
AU  - Cupul-Uicab LA
AD  - Epidemiology Branch, National Institute of Environmental Health Sciences, 
      National Institutes of Health, Department of Health and Human Services, Research 
      Triangle Park, North Carolina 27709, USA. cupuluicabl@niehs.nih.gov
FAU - Skjaerven, Rolv
AU  - Skjaerven R
FAU - Haug, Kjell
AU  - Haug K
FAU - Melve, Kari K
AU  - Melve KK
FAU - Engel, Stephanie M
AU  - Engel SM
FAU - Longnecker, Matthew P
AU  - Longnecker MP
LA  - eng
GR  - P30 ES010126/ES/NIEHS NIH HHS/United States
GR  - 1 U01 NS 047537-01/NS/NINDS NIH HHS/United States
GR  - 1R01HD058008/HD/NICHD NIH HHS/United States
GR  - R01 HD058008/HD/NICHD NIH HHS/United States
GR  - U01 NS047537/NS/NINDS NIH HHS/United States
GR  - N01ES75558/ES/NIEHS NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111129
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/chemically induced/*epidemiology
MH  - Diabetes, Gestational/chemically induced/*epidemiology
MH  - Female
MH  - Humans
MH  - Hypertension/chemically induced/*epidemiology
MH  - Hypertension, Pregnancy-Induced/chemically induced/epidemiology
MH  - Middle Aged
MH  - Norway/epidemiology
MH  - Obesity/chemically induced/*epidemiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/*epidemiology
MH  - Prevalence
MH  - Self Report
MH  - *Tobacco Smoke Pollution
MH  - Young Adult
PMC - PMC3295347
COIS- The authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2011/12/01 06:00
MHDA- 2012/06/27 06:00
PMCR- 2012/03/01
CRDT- 2011/12/01 06:00
PHST- 2011/04/08 00:00 [received]
PHST- 2011/11/29 00:00 [accepted]
PHST- 2011/12/01 06:00 [entrez]
PHST- 2011/12/01 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - ehp.1103789 [pii]
AID - 10.1289/ehp.1103789 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2012 Mar;120(3):355-60. doi: 10.1289/ehp.1103789. Epub 
      2011 Nov 29.