PMID- 22128224
OWN - NLM
STAT- MEDLINE
DCOM- 20120412
LR  - 20221207
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 125
IP  - 2
DP  - 2012 Jan 17
TI  - Associations between lipoprotein(a) levels and cardiovascular outcomes in black 
      and white subjects: the Atherosclerosis Risk in Communities (ARIC) Study.
PG  - 241-9
LID - 10.1161/CIRCULATIONAHA.111.045120 [doi]
AB  - BACKGROUND: On the basis of studies with limited statistical power, 
      lipoprotein(a) [Lp(a)] is not considered a risk factor for cardiovascular disease 
      (CVD) in blacks. We evaluated associations between Lp(a) and incident CVD events 
      in blacks and whites in the Atherosclerosis Risk in Communities (ARIC) study. 
      METHODS AND RESULTS: Plasma Lp(a) was measured in blacks (n=3467) and whites 
      (n=9851). Hazards ratios (HRs) for incident CVD events (coronary heart disease 
      and ischemic strokes) were calculated. Lp(a) levels were higher with wider 
      interindividual variation in blacks (median [interquartile range], 12.8 
      [7.1-21.7] mg/dL) than whites (4.3 [1.7-9.5] mg/dL; P<0.0001). At 20 years of 
      follow-up, 676 CVD events occurred in blacks, and 1821 events occurred in whites. 
      Adjusted HRs (95% confidence interval) per race-specific 1-SD-greater 
      log-transformed Lp(a) were 1.13 (1.04-1.23) for incident CVD, 1.11 (1.00-1.22) 
      for incident coronary heart disease, and 1.21 (1.06-1.39) for ischemic strokes in 
      blacks. For whites, the respective HRs (95% confidence intervals) were 1.09 
      (1.04-1.15), 1.10 (1.05-1.16), and 1.07 (0.97-1.19). Quintile analyses showed 
      that risk for incident CVD was graded but statistically significant only for the 
      highest compared with the lowest quintile (HR [95% confidence interval], 1.35 
      [1.06-1.74] for blacks and 1.27 [1.10-1.47] for whites). Similar results were 
      obtained with the use of Lp(a) cutoffs of </=10 mg/dL, >10 to </=20 mg/dL, >20 to </=30 
      mg/dL, and >30 mg/dL. CONCLUSIONS: Lp(a) levels were positively associated with 
      CVD events. Associations were at least as strong, with a larger range of Lp(a) 
      concentrations, in blacks compared with whites.
CI  - (c) 2011 American Heart Association, Inc.
FAU - Virani, Salim S
AU  - Virani SS
AD  - Michael E. DeBakey Veterans Affairs Medical Center Health Services Research and 
      Development Center of Excellence, Houston, TX, USA.
FAU - Brautbar, Ariel
AU  - Brautbar A
FAU - Davis, Brian C
AU  - Davis BC
FAU - Nambi, Vijay
AU  - Nambi V
FAU - Hoogeveen, Ron C
AU  - Hoogeveen RC
FAU - Sharrett, A Richey
AU  - Sharrett AR
FAU - Coresh, Josef
AU  - Coresh J
FAU - Mosley, Thomas H
AU  - Mosley TH
FAU - Morrisett, Joel D
AU  - Morrisett JD
FAU - Catellier, Diane J
AU  - Catellier DJ
FAU - Folsom, Aaron R
AU  - Folsom AR
FAU - Boerwinkle, Eric
AU  - Boerwinkle E
FAU - Ballantyne, Christie M
AU  - Ballantyne CM
LA  - eng
GR  - HHSN268201100012C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100009I/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100010C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100008C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100007C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100011I/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100011C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100006C/HL/NHLBI NIH HHS/United States
GR  - K23 HL096893/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100005I/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100007I/HL/NHLBI NIH HHS/United States
GR  - CDA 09-028/HX/HSRD VA/United States
GR  - 5K23HL096893-02/HL/NHLBI NIH HHS/United States
GR  - K23 HL096893-02/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100005G/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100008I/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100009C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100005C/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111129
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Lipoprotein(a))
SB  - IM
CIN - Circulation. 2012 Jan 17;125(2):207-9. PMID: 22128225
MH  - Adult
MH  - Aged
MH  - Atherosclerosis/diagnosis/ethnology
MH  - Black People
MH  - Cardiovascular Diseases/diagnosis/*ethnology
MH  - Coronary Disease
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Lipoprotein(a)/*blood
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Risk
MH  - Stroke
MH  - White People
PMC - PMC3760720
MID - NIHMS347200
EDAT- 2011/12/01 06:00
MHDA- 2012/04/13 06:00
PMCR- 2013/09/03
CRDT- 2011/12/01 06:00
PHST- 2011/12/01 06:00 [entrez]
PHST- 2011/12/01 06:00 [pubmed]
PHST- 2012/04/13 06:00 [medline]
PHST- 2013/09/03 00:00 [pmc-release]
AID - CIRCULATIONAHA.111.045120 [pii]
AID - 10.1161/CIRCULATIONAHA.111.045120 [doi]
PST - ppublish
SO  - Circulation. 2012 Jan 17;125(2):241-9. doi: 10.1161/CIRCULATIONAHA.111.045120. 
      Epub 2011 Nov 29.