PMID- 22128242
OWN - NLM
STAT- MEDLINE
DCOM- 20120402
LR  - 20221207
IS  - 1090-0535 (Electronic)
IS  - 1090-0535 (Linking)
VI  - 17
DP  - 2011
TI  - The role of toll-like receptor variants in acute anterior uveitis.
PG  - 2970-7
AB  - PURPOSE: Acute anterior uveitis (AAU) is the most common form of uveitis; 
      however, while it is presumed to have an immunological basis, the precise 
      underlying etiology remains elusive. Toll-like receptors (TLRs) have a key role 
      in linking innate and adaptive immunity, thereby forming a molecular bridge 
      between microbial triggers and the development of AAU. The purpose of this study 
      was to investigate the role of TLR2 and TLR4 gene polymorphisms in the 
      pathogenesis of AAU. METHODS: The study comprised 225 confirmed cases of 
      idiopathic or human leukocyte antigen (HLA) B27 (subtypes B*2701-2759; 
      HLA-B27)-related AAU and 2,534 population-based controls from the Blue Mountains 
      Eye Study. All participants were of Anglo-Celtic descent. Blood samples were 
      collected for DNA extraction and genotyping. A total of 16 single nucleotide 
      polymorphisms (SNPs) were selected for analysis and either directly genotyped or 
      imputed to cover the common variations within the TLR genes. Data were analyzed 
      at the allelic, genotypic and haplotypic levels. RESULTS: Control subjects were 
      significantly older than case subjects (p<0.0001). There was no significant 
      difference in the gender composition between the case and control cohorts 
      (p=0.18). One TLR2 SNP (rs11938228) was found to be associated with AAU at the 
      allelic level (OR=1.28; p=0.017); however this association did not remain 
      following adjustment for age and sex (p=0.067). None of the SNPs at the TLR4 
      locus were found to differ significantly between cases or controls, irrespective 
      of adjustment for age and gender. CONCLUSIONS: This study has confirmed that 
      common TLR variants of moderate effect size do not predispose to AAU, undermining 
      the implication of reported mutations in the selective perturbations of TLR 
      expression and function evident in AAU.
FAU - Pratap, Divya S
AU  - Pratap DS
AD  - Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, Melbourne, Australia.
FAU - Lim, Lyndell L
AU  - Lim LL
FAU - Wang, Jie Jin
AU  - Wang JJ
FAU - Mackey, David A
AU  - Mackey DA
FAU - Kearns, Lisa S
AU  - Kearns LS
FAU - Stawell, Richard J
AU  - Stawell RJ
CN  - Wellcome Trust Case Control Consortium 2
FAU - Burdon, Kathryn P
AU  - Burdon KP
FAU - Mitchell, Paul
AU  - Mitchell P
FAU - Craig, Jamie E
AU  - Craig JE
FAU - Hall, Anthony J
AU  - Hall AJ
FAU - Hewitt, Alex W
AU  - Hewitt AW
LA  - eng
GR  - 085475/08/Z/Wellcome Trust/United Kingdom
GR  - 085475/B/08/Z/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111116
PL  - United States
TA  - Mol Vis
JT  - Molecular vision
JID - 9605351
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (TLR2 protein, human)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Alleles
MH  - Australia/epidemiology
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-B27 Antigen/*genetics/immunology
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide
MH  - Toll-Like Receptor 2/*genetics/immunology
MH  - Toll-Like Receptor 4/*genetics/immunology
MH  - Uveitis, Anterior/ethnology/*genetics/immunology
MH  - *White People
PMC - PMC3224833
EDAT- 2011/12/01 06:00
MHDA- 2012/04/03 06:00
PMCR- 2011/01/01
CRDT- 2011/12/01 06:00
PHST- 2011/10/14 00:00 [received]
PHST- 2011/11/08 00:00 [accepted]
PHST- 2011/12/01 06:00 [entrez]
PHST- 2011/12/01 06:00 [pubmed]
PHST- 2012/04/03 06:00 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - 320 [pii]
AID - 2011MOLVIS0463 [pii]
PST - ppublish
SO  - Mol Vis. 2011;17:2970-7. Epub 2011 Nov 16.