PMID- 22128749
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20120106
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 79
IP  - 2
DP  - 2012 Feb
TI  - Susceptibility to pulmonary tuberculosis in Iranian individuals is not affected 
      by compound KIR/HLA genotype.
PG  - 90-6
LID - 10.1111/j.1399-0039.2011.01812.x [doi]
AB  - Natural killer (NK) cells have distinctive functional capacities that are likely 
      to contribute both to innate and adaptive immunity to Mycobacterium tuberculosis. 
      Killer cell immunoglobulin-like receptors (KIR) and their ligands, i.e. human 
      leukocyte antigen (HLA) class I molecules contribute partly in regulation of NK 
      cell activity. In this study, the impact of compound KIR/HLA genotype on 
      susceptibility to pulmonary tuberculosis (TB) has been evaluated in Iranian 
      individuals. A total of 107 TB patients and 100 matched healthy controls were 
      genotyped for 17 KIR genes and their three major HLA class I ligand groups (-C1, 
      -C2 and -Bw4: -B Bw4(Ile80) , -B Bw4(Thr80) and -A Bw4) by a polymerase chain 
      reaction-sequence-specific primers assay. Various analyses including distribution 
      of KIR and HLA ligand genes and genotypes, frequency of inhibitory and activating 
      KIR+HLA combinations and compound genotype status regarding balance of inhibitory 
      and activating components showed no significant difference between patient and 
      control groups. These findings may suggest that compound KIR/HLA genotype has no 
      major impact on limiting Mycobacterium tuberculosis infection.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Tajik, N
AU  - Tajik N
AD  - Immunology Research Center (IRC), Tehran University of Medical Sciences, Tehran, 
      Iran. ntajik@tums.ac.ir
FAU - Shah-hosseini, A
AU  - Shah-hosseini A
FAU - Mohammadi, A
AU  - Mohammadi A
FAU - Jafari, M
AU  - Jafari M
FAU - Nasiri, M
AU  - Nasiri M
FAU - Radjabzadeh, M F
AU  - Radjabzadeh MF
FAU - Farnia, P
AU  - Farnia P
FAU - Jalali, A
AU  - Jalali A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111130
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - *Adaptive Immunity
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Humans
MH  - *Immunity, Innate
MH  - Iran
MH  - Killer Cells, Natural/immunology/*metabolism
MH  - Male
MH  - Mycobacterium tuberculosis/*immunology
MH  - Odds Ratio
MH  - Polymerase Chain Reaction
MH  - Receptors, KIR/*genetics/immunology
MH  - Tuberculosis, Pulmonary/*genetics/immunology/microbiology
EDAT- 2011/12/02 06:00
MHDA- 2012/08/15 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - 10.1111/j.1399-0039.2011.01812.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2012 Feb;79(2):90-6. doi: 10.1111/j.1399-0039.2011.01812.x. Epub 
      2011 Nov 30.