PMID- 22129469
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20161125
IS  - 1879-1506 (Electronic)
IS  - 0003-9969 (Linking)
VI  - 57
IP  - 3
DP  - 2012 Mar
TI  - Decreased TNF-alpha gene expression in periodontal ligature in MSG-obese rats: a 
      possible protective effect of hypothalamic obesity against periodontal disease?
PG  - 300-6
LID - 10.1016/j.archoralbio.2011.08.024 [doi]
AB  - The prevalence of obesity is increasing globally. There is evidence that the 
      uncontrolled energetic metabolism in obese patients can accelerate periodontal 
      disease. Therefore, the aim of this study was evaluate the possible relationship 
      between hypothalamic obesity induced by neonatal treatment with MSG and 
      experimental periodontal disease. Newborn male Wistar rats received subcutaneous 
      injections in the cervical region, of 4g/Kg/day of body weight (BW) of MSG (MSG 
      group) or hypertonic saline solution, 1.25/kg/day BW (control group, CTL). At 70 
      days of life periodontal disease was induced in these animals. After they were 
      sacrificed, radiographic analyses of alveolar bone resorption and Tumor Necrosis 
      Factor alpha (TNFalpha) gene expression in gingival tissue were performed. The neonatal 
      treatment with MSG did not affect the concentration of plasma glucose and 
      cholesterol (CHOL). However, plasma insulin, non-esterified fatty acids (NEFA) 
      and triglycerides (TG) leves were higher in MSG compared with CTL group. The 
      alveolar bone resorption was 44% lower in MSG-obese rats compared with CTL rats. 
      In the presence of periodontal ligature, there was an increase in this parameter 
      in all groups. The TNFalpha gene expression, an inflammatory marker, in periodontal 
      tissue was similar in obese and CTL rats. The presence of ligature increased TNFalpha 
      gene expression in both groups, but in a lower extension in MSG-obese rats. In 
      conclusion these results suggested that hypothalamic obesity may produce a 
      protective effect against periodontal disease, however further research is needed 
      to understand the mechanisms involved in this process.
CI  - Copyright A(c) 2011 Elsevier Ltd. All rights reserved.
FAU - Brandelero, Savio Jr
AU  - Brandelero S Jr
AD  - Biological Sciences and Health Center, University of State of West of Parana, 
      Cascavel, Brazil.
FAU - Bonfleur, Maria Lucia
AU  - Bonfleur ML
FAU - Ribeiro, Rosane Aparecida
AU  - Ribeiro RA
FAU - Vanzela, Emerielle Cristine
AU  - Vanzela EC
FAU - Nassar, Carlos Augusto
AU  - Nassar CA
FAU - Nassar, Patricia Oehlmeyer
AU  - Nassar PO
FAU - Balbo, Sandra Lucinei
AU  - Balbo SL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111129
PL  - England
TA  - Arch Oral Biol
JT  - Archives of oral biology
JID - 0116711
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - W81N5U6R6U (Sodium Glutamate)
SB  - IM
MH  - *Alveolar Bone Loss/diagnostic imaging/pathology/prevention & control
MH  - Animals
MH  - Cholesterol/blood
MH  - Down-Regulation
MH  - Fatty Acids, Nonesterified/blood
MH  - Gene Expression
MH  - Gingiva/*metabolism
MH  - Hypothalamus/metabolism
MH  - Male
MH  - Obesity/blood/chemically induced/*metabolism
MH  - Radiography
MH  - Rats
MH  - Rats, Wistar
MH  - Real-Time Polymerase Chain Reaction
MH  - Sodium Glutamate
MH  - Triglycerides/blood
MH  - Tumor Necrosis Factor-alpha/genetics/*metabolism
EDAT- 2011/12/02 06:00
MHDA- 2012/06/27 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/03/23 00:00 [received]
PHST- 2011/07/27 00:00 [revised]
PHST- 2011/08/29 00:00 [accepted]
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
AID - S0003-9969(11)00278-0 [pii]
AID - 10.1016/j.archoralbio.2011.08.024 [doi]
PST - ppublish
SO  - Arch Oral Biol. 2012 Mar;57(3):300-6. doi: 10.1016/j.archoralbio.2011.08.024. 
      Epub 2011 Nov 29.