PMID- 22131200
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1873-961X (Electronic)
IS  - 1873-9601 (Print)
IS  - 1873-9601 (Linking)
VI  - 6
IP  - 1
DP  - 2012 Mar
TI  - MEK/ERK inhibitors: proof-of-concept studies in lung fibrosis.
PG  - 59-60
LID - 10.1007/s12079-011-0156-9 [doi]
AB  - There is no therapy for chronic fibroproliferative diseases, in spite of the fact 
      that current health statistics suggest that these (which include cardiovascular 
      disease, pulmonary fibrosis, diabetic nephropathy, liver cirrhosis and systemic 
      sclerosis) have been estimated to cause approximately 45% of the deaths in the 
      developed world. Recently, many studies have shown that mitogen activated protein 
      kinases (MAPKs) are activated in response to fibrogenic agents and contribute to 
      the formation and function of the myofibroblast, the critical cell type 
      responsible for excessive scarring. A recent report by Madala and colleagues (Am 
      J Respir Cell Mol Biol, 2011) has provided a proof-of-concept study showing that 
      the specific MEK inhibitor ARRY-142886 (ARRY) can both suppress the progression 
      of fibrosis and reverse an animal model of lung fibrosis. Thus MEK inhibition 
      could be a valuable method to treat lung fibrosis.
FAU - Leask, Andrew
AU  - Leask A
AD  - Departments of Dentistry and Physiology and Pharmacology, University of Western 
      Ontario, Dental Sciences Building, London, ON, Canada, N6A 5C1, 
      Andrew.leask@schulich.uwo.ca.
LA  - eng
PT  - Journal Article
DEP - 20111201
PL  - Netherlands
TA  - J Cell Commun Signal
JT  - Journal of cell communication and signaling
JID - 101308338
PMC - PMC3271198
EDAT- 2011/12/02 06:00
MHDA- 2011/12/02 06:01
PMCR- 2012/03/01
CRDT- 2011/12/02 06:00
PHST- 2011/11/21 00:00 [received]
PHST- 2011/11/22 00:00 [accepted]
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2011/12/02 06:01 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - 156 [pii]
AID - 10.1007/s12079-011-0156-9 [doi]
PST - ppublish
SO  - J Cell Commun Signal. 2012 Mar;6(1):59-60. doi: 10.1007/s12079-011-0156-9. Epub 
      2011 Dec 1.