PMID- 22131805
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20211021
IS  - 1110-7251 (Electronic)
IS  - 1110-7243 (Print)
IS  - 1110-7243 (Linking)
VI  - 2011
DP  - 2011
TI  - T cells as vehicles for cancer vaccination.
PG  - 417403
LID - 10.1155/2011/417403 [doi]
LID - 417403
AB  - The success of cancer vaccines is dependent on the delivery of tumor-associated 
      antigens (TAAs) within lymphoid tissue in the context of costimulatory molecules 
      and immune stimulatory cytokines. Dendritic cells (DCs) are commonly utilized to 
      elicit antitumor immune responses due to their attractive costimulatory molecule 
      and cytokine expression profile. However, the efficacy of DC-based vaccines is 
      limited by the poor viability and lymph-node migration of exogenously generated 
      DCs in vivo. Alternatively, adoptively transferred T cells persist for long 
      periods of time in vivo and readily migrate between the lymphoid and vascular 
      compartments. In addition, T cells may be genetically modified to express both 
      TAA and DC-activating molecules, suggesting that T cells may be ideal candidates 
      to serve as cellular vehicles for antigen delivery to lymph node-resident DCs in 
      vivo. This paper discusses the concept of using T cells to induce tumor-specific 
      immunity for vaccination against cancer.
FAU - Bear, Adham S
AU  - Bear AS
AD  - Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist 
      Hospital and Texas Children's Hospital, Houston, TX 77030, USA.
FAU - Cruz, Conrad R
AU  - Cruz CR
FAU - Foster, Aaron E
AU  - Foster AE
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111027
PL  - United States
TA  - J Biomed Biotechnol
JT  - Journal of biomedicine & biotechnology
JID - 101135740
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Cancer Vaccines)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adoptive Transfer
MH  - Antigens, Neoplasm/genetics/*immunology
MH  - Cancer Vaccines/*immunology
MH  - Cytokines/genetics/immunology
MH  - Dendritic Cells/*immunology
MH  - Gene Expression Profiling
MH  - Humans
MH  - Lymph Nodes/immunology
MH  - Neoplasms/*therapy
MH  - T-Lymphocytes/*immunology/*transplantation
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - Transfection
PMC - PMC3205726
EDAT- 2011/12/02 06:00
MHDA- 2012/03/23 06:00
PMCR- 2011/10/27
CRDT- 2011/12/02 06:00
PHST- 2011/07/07 00:00 [received]
PHST- 2011/08/30 00:00 [accepted]
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
PHST- 2011/10/27 00:00 [pmc-release]
AID - 10.1155/2011/417403 [doi]
PST - ppublish
SO  - J Biomed Biotechnol. 2011;2011:417403. doi: 10.1155/2011/417403. Epub 2011 Oct 
      27.