PMID- 22132323
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2090-0732 (Electronic)
IS  - 2090-0724 (Print)
IS  - 2090-0724 (Linking)
VI  - 2011
DP  - 2011
TI  - T2DM: Why Epigenetics?
PG  - 647514
LID - 10.1155/2011/647514 [doi]
LID - 647514
AB  - Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder influenced by 
      interactions between genetic and environmental factors. Epigenetics conveys 
      specific environmental influences into phenotypic traits through a variety of 
      mechanisms that are often installed in early life, then persist in differentiated 
      tissues with the power to modulate the expression of many genes, although 
      undergoing time-dependent alterations. There is still no evidence that 
      epigenetics contributes significantly to the causes or transmission of T2DM from 
      one generation to another, thus, to the current environment-driven epidemics, but 
      it has become so likely, as pointed out in this paper, that one can expect an 
      efflorescence of epigenetic knowledge about T2DM in times to come.
FAU - Fradin, Delphine
AU  - Fradin D
AD  - INSERM U986, Bicetre Hospital, University of Paris-Sud, Le Kremlin-Bicetre, 
      France.
FAU - Bougneres, Pierre
AU  - Bougneres P
LA  - eng
PT  - Journal Article
DEP - 20111103
PL  - United States
TA  - J Nutr Metab
JT  - Journal of nutrition and metabolism
JID - 101526296
PMC - PMC3216274
EDAT- 2011/12/02 06:00
MHDA- 2011/12/02 06:01
PMCR- 2011/11/03
CRDT- 2011/12/02 06:00
PHST- 2011/08/11 00:00 [received]
PHST- 2011/09/20 00:00 [accepted]
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2011/12/02 06:01 [medline]
PHST- 2011/11/03 00:00 [pmc-release]
AID - 10.1155/2011/647514 [doi]
PST - ppublish
SO  - J Nutr Metab. 2011;2011:647514. doi: 10.1155/2011/647514. Epub 2011 Nov 3.