PMID- 22132698
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20131121
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 39
IP  - 2
DP  - 2012 Feb
TI  - Three siblings with systemic lupus erythematosus.
PG  - 164-7
LID - 10.1111/j.1346-8138.2011.01333.x [doi]
AB  - We present the cases of three siblings with systemic lupus erythematosus (SLE). 
      The diagnosis was made when the sisters were of age 21, 25 and 28 years. They 
      shared some clinical features, including typical facial rash, photosensitivity 
      and Raynaud's phenomenon, and tested positive for antinuclear antibodies. 
      However, their symptoms and clinical courses varied. Human leukocyte antigen 
      (HLA) typing revealed that DR4 and A2 were present in all three sisters, while 
      HLA type A11, B35 and B54 were each found in two of the three sisters. The two 
      elder sisters developed lupus glomerulonephritis 8 and 11 years after the onset 
      of SLE. It is suggested that there are genes responsible for the onset of the 
      disease and also unknown regulatory genes other than HLA result in different 
      phenotypes.
CI  - (c) 2011 Japanese Dermatological Association.
FAU - Shu, En
AU  - Shu E
AD  - Department of Dermatology, Gifu University Graduate School of Medicine Department 
      of Dermatology, Kizawa Memorial Hospital, Gifu, Japan. gif142@gifu-u.ac.jp
FAU - Ichiki, Yoshiro
AU  - Ichiki Y
FAU - Moriya, Chie
AU  - Moriya C
FAU - Iwata, Hiroaki
AU  - Iwata H
FAU - Kitajima, Yasuo
AU  - Kitajima Y
FAU - Seishima, Mariko
AU  - Seishima M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20111202
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Dermatologic Agents)
RN  - 0 (HLA Antigens)
RN  - 9PHQ9Y1OLM (Prednisolone)
RN  - MRK240IY2L (Azathioprine)
SB  - IM
MH  - Adult
MH  - Antibodies, Antinuclear/blood/immunology
MH  - Azathioprine/therapeutic use
MH  - Dermatologic Agents/therapeutic use
MH  - Exanthema/diagnosis
MH  - Female
MH  - HLA Antigens/analysis/genetics/immunology
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*diagnosis/drug therapy/genetics
MH  - Photosensitivity Disorders/diagnosis/immunology
MH  - Prednisolone/therapeutic use
MH  - Raynaud Disease/diagnosis/immunology
MH  - Siblings
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/12/03 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/12/03 06:00
PHST- 2011/12/03 06:00 [entrez]
PHST- 2011/12/03 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.1111/j.1346-8138.2011.01333.x [doi]
PST - ppublish
SO  - J Dermatol. 2012 Feb;39(2):164-7. doi: 10.1111/j.1346-8138.2011.01333.x. Epub 
      2011 Dec 2.