PMID- 22132892
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20211021
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 167
IP  - 1
DP  - 2012 Jan
TI  - Up-regulation of chemokine C-C ligand 2 (CCL2) and C-X-C chemokine 8 (CXCL8) 
      expression by monocytes in chronic idiopathic urticaria.
PG  - 129-36
LID - 10.1111/j.1365-2249.2011.04485.x [doi]
AB  - The disturbed cytokine-chemokine network could play an important role in the 
      onset of diseases with inflammatory processes such as chronic idiopathic 
      urticaria (CIU). Our main objectives were to evaluate the relation between 
      proinflammatory chemokine serum levels from CIU patients and their response to 
      autologous skin test (ASST) and basophil histamine release (BHR). We also aimed 
      to assess the chemokine secretion by peripheral blood mononuclear cells (PBMC) 
      upon polyclonal stimulus and to evaluate chemokine C-C ligand 2/C-X-C chemokine 8 
      (CCL2/CXCL8) and Toll-like receptor-4 (TLR-4) expression in monocytes. We 
      observed significantly higher serum levels of the CXCL8, CXCL9, CXCL10 and CCL2 
      in CIU patients compared to the healthy group, regardless of the BHR or ASST 
      response. The basal secretion of CCL2 by PBMC or induced by Staphylococcus aureus 
      enterotoxin A (SEA) was higher in CIU patients than in the control group, as well 
      as for CXCL8 and CCL5 secretions upon phytohaemagglutinin stimulation. Also, 
      up-regulation of CCL2 and CXCL8 mRNA expression was found in monocytes of 
      patients upon SEA stimulation. The findings showed a high responsiveness of 
      monocytes through CCL2/CXCL8 expression, contributing to the creation of a 
      proinflammatory environment in CIU.
CI  - (c) 2011 The Authors. Clinical and Experimental Immunology (c) 2011 British Society 
      for Immunology.
FAU - Santos, J C
AU  - Santos JC
AD  - Laboratory of Dermatology and Immunodeficiencies (LIM-56), Department of 
      Dermatology, Medical School of University of Sao Paulo, Sao Paulo, Brazil.
FAU - de Brito, C A
AU  - de Brito CA
FAU - Futata, E A
AU  - Futata EA
FAU - Azor, M H
AU  - Azor MH
FAU - Orii, N M
AU  - Orii NM
FAU - Maruta, C W
AU  - Maruta CW
FAU - Rivitti, E A
AU  - Rivitti EA
FAU - Duarte, A J S
AU  - Duarte AJ
FAU - Sato, M N
AU  - Sato MN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (CCL2 protein, human)
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokines)
RN  - 0 (Enterotoxins)
RN  - 0 (Interleukin-8)
RN  - 0 (Phytohemagglutinins)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 4)
RN  - 37337-57-8 (enterotoxin A, Staphylococcal)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Basophil Degranulation Test
MH  - Chemokine CCL2/*biosynthesis/genetics/physiology
MH  - Chemokines/blood
MH  - Chronic Disease
MH  - Enterotoxins/pharmacology
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Inflammation
MH  - Interleukin-8/*biosynthesis/genetics/physiology
MH  - Leukocytes, Mononuclear/drug effects/*metabolism
MH  - Lymphocyte Activation/drug effects
MH  - Male
MH  - Middle Aged
MH  - Monocytes/drug effects/*metabolism
MH  - Phytohemagglutinins/pharmacology
MH  - Real-Time Polymerase Chain Reaction
MH  - Skin Tests
MH  - Toll-Like Receptor 4/biosynthesis/genetics
MH  - Up-Regulation/drug effects
MH  - Urticaria/blood/*genetics/immunology
MH  - Young Adult
PMC - PMC3248094
EDAT- 2011/12/03 06:00
MHDA- 2012/01/24 06:00
PMCR- 2013/01/01
CRDT- 2011/12/03 06:00
PHST- 2011/12/03 06:00 [entrez]
PHST- 2011/12/03 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.1111/j.1365-2249.2011.04485.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2012 Jan;167(1):129-36. doi: 10.1111/j.1365-2249.2011.04485.x.