PMID- 22133868 OWN - NLM STAT- MEDLINE DCOM- 20120411 LR - 20170118 IS - 1660-2129 (Electronic) IS - 1660-2129 (Linking) VI - 119 IP - 4 DP - 2011 TI - Dendritic cells in experimental renal inflammation--Part I. PG - e83-90 LID - 10.1159/000332029 [doi] AB - Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses. While descriptions of cells with dendritic morphology in rodent kidneys date back to the early 1970s, a network of DCs in the mouse kidney has only recently been described. DCs acquire distinct phenotypic and functional characteristics depending on the microenvironment and the disease stages. Concomitantly, their communication with cells of the adaptive immunity might have tissue-protective or tissue-deleterious consequences. This review summarizes results from recent studies on the role of DCs in experimental renal inflammation. CI - Copyright (c) 2011 S. Karger AG, Basel. FAU - Lindenmeyer, Maja AU - Lindenmeyer M AD - Division of Nephrology, University Hospital Zurich, and Institute of Anatomy, University of Zurich, Zurich, Switzerland. FAU - Noessner, Elfriede AU - Noessner E FAU - Nelson, Peter J AU - Nelson PJ FAU - Segerer, Stephan AU - Segerer S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20111104 PL - Switzerland TA - Nephron Exp Nephrol JT - Nephron. Experimental nephrology JID - 101159770 SB - IM MH - Animals MH - Dendritic Cells/*immunology MH - *Disease Models, Animal MH - Humans MH - Kidney/*immunology/*pathology MH - Mice MH - Nephritis/*immunology/*pathology EDAT- 2011/12/03 06:00 MHDA- 2012/04/12 06:00 CRDT- 2011/12/03 06:00 PHST- 2011/12/03 06:00 [entrez] PHST- 2011/12/03 06:00 [pubmed] PHST- 2012/04/12 06:00 [medline] AID - 000332029 [pii] AID - 10.1159/000332029 [doi] PST - ppublish SO - Nephron Exp Nephrol. 2011;119(4):e83-90. doi: 10.1159/000332029. Epub 2011 Nov 4.