PMID- 22133869
OWN - NLM
STAT- MEDLINE
DCOM- 20120411
LR  - 20170118
IS  - 1660-2129 (Electronic)
IS  - 1660-2129 (Linking)
VI  - 119
IP  - 4
DP  - 2011
TI  - Dendritic cells in human renal inflammation--Part II.
PG  - e91-8
LID - 10.1159/000332032 [doi]
AB  - Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting 
      cells that act as master regulators of acquired and innate immune responses. 
      Here, we review the available information on their role in human renal 
      inflammation. In the 1980s and early 1990s, major histocompatibility complex 
      class II antigen- (HLA-DR) positive DCs were first described in normal human 
      kidneys and in the interstitium of kidneys from patients with glomerulonephritis. 
      Several DC subtypes were subsequently distinguished based on their expression of 
      CD1c/BDCA-1, CD141/BDCA-3 and CD209/DC-SIGN (in combination with HLA-DR). These 
      cells were almost exclusively found in the tubulointerstitium, with increased 
      numbers seen during glomerulonephritis. It appears that the human renal 
      tubulointerstitium harbors different DC types which allow the collection of both 
      exogenous as well as endogenous antigens. Plasmacytoid DCs have a plasma 
      cell-like morphology and were commonly found within nodular tubulointerstitial 
      infiltrates. Follicular DCs are rarely seen, but show a predominant localization 
      in organized infiltrates. CD207/langerin is a marker for Langerhans cells. 
      Langerin-positive cells have been found in association with the collecting ducts 
      and urothelium. A functional characterization of these subtypes has been hampered 
      by the difficulty of obtaining samples for analysis. However, these studies are 
      clearly required to define the role of DCs and DC subsets in the pathophysiology 
      of renal disease.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Noessner, Elfriede
AU  - Noessner E
AD  - Institute of Molecular Immunology, Helmholtz Zentrum Munchen, German Research 
      Center for Environmental Health, Munich, Germany.
FAU - Lindenmeyer, Maja
AU  - Lindenmeyer M
FAU - Nelson, Peter J
AU  - Nelson PJ
FAU - Segerer, Stephan
AU  - Segerer S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111104
PL  - Switzerland
TA  - Nephron Exp Nephrol
JT  - Nephron. Experimental nephrology
JID - 101159770
RN  - 0 (Cytokines)
SB  - IM
MH  - Cytokines/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Kidney/*immunology/*pathology
MH  - Nephritis/*immunology/*pathology
EDAT- 2011/12/03 06:00
MHDA- 2012/04/12 06:00
CRDT- 2011/12/03 06:00
PHST- 2011/12/03 06:00 [entrez]
PHST- 2011/12/03 06:00 [pubmed]
PHST- 2012/04/12 06:00 [medline]
AID - 000332032 [pii]
AID - 10.1159/000332032 [doi]
PST - ppublish
SO  - Nephron Exp Nephrol. 2011;119(4):e91-8. doi: 10.1159/000332032. Epub 2011 Nov 4.