PMID- 22135401
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20220331
IS  - 1942-0080 (Electronic)
IS  - 1941-9651 (Linking)
VI  - 5
IP  - 1
DP  - 2012 Jan
TI  - Intermediate-signal-intensity late gadolinium enhancement predicts ventricular 
      tachyarrhythmias in patients with hypertrophic cardiomyopathy.
PG  - 78-85
LID - 10.1161/CIRCIMAGING.111.963819 [doi]
AB  - BACKGROUND: In hypertrophic cardiomyopathy (HCM), the arrhythmic potential 
      associated with a variety of left ventricular myocardial signal intensities 
      evident on contrast-enhanced cardiovascular magnetic resonance with late 
      gadolinium enhancement (LGE) is unresolved. METHODS AND RESULTS: In 145 HCM 
      patients (43+/-15 years old), visually identified areas of LGE in left ventricle 
      were analyzed quantitatively for intermediate (>/=4 but <6 SD) and high (>/=6 SD 
      above the mean signal intensity of normal myocardium) LGE signal intensity 
      (LGE-SI). Ambulatory Holter ECGs were obtained within 7.8+/-8.3 weeks of 
      cardiovascular magnetic resonance. HCM patients with nonsustained ventricular 
      tachycardia, ventricular couplets, and premature ventricular contractions showed 
      greater amounts of intermediate LGE-SI (17+/-7 versus 10+/-10 g, 16+/-10 versus 10+/-11 
      g, and 13+/-8 versus 10+/-13 g, respectively; P=0.003 to <0.001) and greater amounts 
      of high LGE-SI (15+/-6 versus 10+/-8 g, 14+/-9 versus 10+/-12 g, and 12+/-7 versus 10+/-8 g, 
      respectively; P=0.02-0.003) than patients without these arrhythmias. In HCM 
      patients with either nonsustained ventricular tachycardia, couplets, or premature 
      ventricular contractions, the extent of intermediate LGE-SI exceeded that of high 
      LGE-SI (17+/-7 versus 15+/-6 g, 16+/-10 versus 14+/-9 g, and 13+/-8 versus 12+/-7 g, 
      respectively; P=0.01-0.04). In addition, the receiver operating characteristic 
      area under the curve established intermediate LGE-SI as a better discriminator of 
      patients with nonsustained ventricular tachycardia than was high LGE-SI, with 7 
      additional patients with this arrhythmia identified. CONCLUSIONS: In patients 
      with HCM, intermediate LGE-SI is a better predictor of ventricular 
      tachyarrhythmias (including nonsustained ventricular tachycardia, a risk factor 
      for sudden death) than is high LGE-SI. Longitudinal studies in larger HCM cohorts 
      are justified to define the independent prognostic impact of intermediate LGE-SI.
FAU - Appelbaum, Evan
AU  - Appelbaum E
AD  - PERFUSE Core Laboratory and Data Coordinating Center, Beth Israel Deaconess 
      Medical Center, Harvard Medical School, Boston, MA 02215, USA. 
      eappelba@bidmc.harvard.edu
FAU - Maron, Barry J
AU  - Maron BJ
FAU - Adabag, Selcuk
AU  - Adabag S
FAU - Hauser, Thomas H
AU  - Hauser TH
FAU - Lesser, John R
AU  - Lesser JR
FAU - Haas, Tammy S
AU  - Haas TS
FAU - Riley, Anne B
AU  - Riley AB
FAU - Harrigan, Caitlin J
AU  - Harrigan CJ
FAU - Delling, Francesca N
AU  - Delling FN
FAU - Udelson, James E
AU  - Udelson JE
FAU - Gibson, C Michael
AU  - Gibson CM
FAU - Manning, Warren J
AU  - Manning WJ
FAU - Maron, Martin S
AU  - Maron MS
LA  - eng
PT  - Journal Article
DEP - 20111201
PL  - United States
TA  - Circ Cardiovasc Imaging
JT  - Circulation. Cardiovascular imaging
JID - 101479935
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
CIN - Circ Cardiovasc Imaging. 2012 Jan;5(1):2-5. PMID: 22253332
CIN - Circ Cardiovasc Imaging. 2012 May 1;5(3):e38. PMID: 22592016
CIN - JACC Cardiovasc Imaging. 2013 Nov;6(11):1216-8. PMID: 24229776
MH  - Adult
MH  - Cardiomyopathy, Hypertrophic/complications/*pathology
MH  - Cohort Studies
MH  - *Contrast Media
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Predictive Value of Tests
MH  - Tachycardia, Ventricular/complications/*pathology
EDAT- 2011/12/03 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/12/03 06:00
PHST- 2011/12/03 06:00 [entrez]
PHST- 2011/12/03 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - CIRCIMAGING.111.963819 [pii]
AID - 10.1161/CIRCIMAGING.111.963819 [doi]
PST - ppublish
SO  - Circ Cardiovasc Imaging. 2012 Jan;5(1):78-85. doi: 
      10.1161/CIRCIMAGING.111.963819. Epub 2011 Dec 1.