PMID- 22136114
OWN - NLM
STAT- MEDLINE
DCOM- 20120607
LR  - 20220316
IS  - 1468-1293 (Electronic)
IS  - 1464-2662 (Print)
IS  - 1464-2662 (Linking)
VI  - 13
IP  - 5
DP  - 2012 May
TI  - Metabolic abnormalities and viral replication are associated with biomarkers of 
      vascular dysfunction in HIV-infected children.
PG  - 264-75
LID - 10.1111/j.1468-1293.2011.00970.x [doi]
AB  - OBJECTIVES: HIV-infected children may be at risk for premature cardiovascular 
      disease. We compared levels of biomarkers of vascular dysfunction in HIV-infected 
      children (with and without hyperlipidaemia) with those in HIV-exposed, uninfected 
      (HEU) children enrolled in the Pediatric HIV/AIDS Cohort Study (PHACS), and 
      determined factors associated with these biomarkers. METHODS: A prospective 
      cohort study was carried out. Biomarkers of inflammation [C-reactive protein 
      (CRP), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP1)], 
      coagulant dysfunction (fibrinogen and P-selectin), endothelial dysfunction 
      [soluble intracellular cell adhesion molecule-1 (sICAM), soluble vascular cell 
      adhesion molecule-1 (sVCAM) and E-selectin], and metabolic dysfunction 
      (adiponectin) were measured in 226 HIV-infected and 140 HEU children. 
      Anthropometry, body composition, lipids, glucose, insulin, HIV disease severity, 
      and antiretroviral therapy were recorded. RESULTS: The median ages of the 
      children were 12.3 years in the HIV-infected group and 10.1 years in the HEU 
      group. Body mass index (BMI) z-scores, waist and hip circumferences, and 
      percentage body fat were lower in the HIV-infected children. Total and 
      non-high-density lipoprotein (HDL) cholesterol and triglycerides were higher in 
      HIV-infected children. HIV-infected children also had higher MCP-1, fibrinogen, 
      sICAM and sVCAM levels. In multivariable analyses in the HIV-infected children 
      alone, BMI z-score was associated with higher CRP and fibrinogen, but lower MCP-1 
      and sVCAM. Unfavourable lipid profiles were positively associated with IL-6, 
      MCP-1, fibrinogen, and P- and E-selectin, whereas increased HIV viral load was 
      associated with markers of inflammation (MCP-1 and CRP) and endothelial 
      dysfunction (sICAM and sVCAM). CONCLUSIONS: HIV-infected children have higher 
      levels of biomarkers of vascular dysfunction than do HEU children. Risk factors 
      associated with higher biomarkers include unfavourable lipid levels and active 
      HIV replication.
CI  - (c) 2011 British HIV Association.
FAU - Miller, T I
AU  - Miller TI
AD  - Department of Pediatrics, Division of Pediatric Clinical Research, Miller School 
      of Medicine at the University of Miami, Miami, FL, USA.
FAU - Borkowsky, W
AU  - Borkowsky W
FAU - DiMeglio, L A
AU  - DiMeglio LA
FAU - Dooley, L
AU  - Dooley L
FAU - Geffner, M E
AU  - Geffner ME
FAU - Hazra, R
AU  - Hazra R
FAU - McFarland, E J
AU  - McFarland EJ
FAU - Mendez, A J
AU  - Mendez AJ
FAU - Patel, K
AU  - Patel K
FAU - Siberry, G K
AU  - Siberry GK
FAU - Van Dyke, R B
AU  - Van Dyke RB
FAU - Worrell, C J
AU  - Worrell CJ
FAU - Jacobson, D L
AU  - Jacobson DL
CN  - Pediatric HIV/AIDS Cohort Study (PHACS)
FAU - Shearer, William
AU  - Shearer W
FAU - Cooper, Norma
AU  - Cooper N
FAU - Harris, Lynette
AU  - Harris L
FAU - Purswani, Murli
AU  - Purswani M
FAU - Baig, Mahboobullah
AU  - Baig M
FAU - Cintron, Anna
AU  - Cintron A
FAU - Puga, Ana
AU  - Puga A
FAU - Navarro, Sandra
AU  - Navarro S
FAU - Patton, Doyle
AU  - Patton D
FAU - Burchett, Sandra
AU  - Burchett S
FAU - Karthas, Nancy
AU  - Karthas N
FAU - Kammerer, Betsy
AU  - Kammerer B
FAU - Yogev, Ram
AU  - Yogev R
FAU - Malee, Kathleen
AU  - Malee K
FAU - Hunter, Scott
AU  - Hunter S
FAU - Cagwin, Eric
AU  - Cagwin E
FAU - Wiznia, Andrew
AU  - Wiznia A
FAU - Burey, Marlene
AU  - Burey M
FAU - Nozyce, Molly
AU  - Nozyce M
FAU - Chen, Janet
AU  - Chen J
FAU - Gobs, Elizabeth
AU  - Gobs E
FAU - Grant, Mitzie
AU  - Grant M
FAU - Knapp, Katherine
AU  - Knapp K
FAU - Allison, Kim
AU  - Allison K
FAU - Garvie, Patricia
AU  - Garvie P
FAU - Acevedo-Flores, Midnela
AU  - Acevedo-Flores M
FAU - Rios, Heida
AU  - Rios H
FAU - Olivera, Vivian
AU  - Olivera V
FAU - Silio, Margarita
AU  - Silio M
FAU - Borne, Cheryl
AU  - Borne C
FAU - Sirois, Patricia
AU  - Sirois P
FAU - Spector, Stephen
AU  - Spector S
FAU - Norris, Kim
AU  - Norris K
FAU - Nichols, Sharon
AU  - Nichols S
FAU - McFarland, Elizabeth
AU  - McFarland E
FAU - Barr, Emily
AU  - Barr E
FAU - Chambers, Carrie
AU  - Chambers C
FAU - Watson, Douglas
AU  - Watson D
FAU - Messenger, Nicole
AU  - Messenger N
FAU - Belanger, Rose
AU  - Belanger R
FAU - Dieudonne, Arry
AU  - Dieudonne A
FAU - Bettica, Linda
AU  - Bettica L
FAU - Adubato, Susan
AU  - Adubato S
FAU - Scott, Gwendolyn
AU  - Scott G
FAU - Himic, Lisa
AU  - Himic L
FAU - Willen, Elizabeth
AU  - Willen E
LA  - eng
GR  - U01 HD052104/HD/NICHD NIH HHS/United States
GR  - U01 HD052104-01/HD/NICHD NIH HHS/United States
GR  - UL1 RR025780/RR/NCRR NIH HHS/United States
GR  - R01 HL095127/HL/NHLBI NIH HHS/United States
GR  - R01 HL095127-03/HL/NHLBI NIH HHS/United States
GR  - U01 HD052102/HD/NICHD NIH HHS/United States
GR  - U01 HD052102-04/HD/NICHD NIH HHS/United States
GR  - U01 HD052104-08/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111204
PL  - England
TA  - HIV Med
JT  - HIV medicine
JID - 100897392
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokine CCL2)
RN  - 0 (E-Selectin)
RN  - 0 (Interleukin-6)
RN  - 0 (P-Selectin)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Cardiovascular Diseases/*blood
MH  - Cell Adhesion Molecules/blood
MH  - Chemokine CCL2/blood
MH  - Child
MH  - Cohort Studies
MH  - E-Selectin/blood
MH  - Female
MH  - Fibrinogen/analysis
MH  - HIV Infections/*blood/physiopathology
MH  - HIV-1/*physiology
MH  - Humans
MH  - Hyperlipidemias/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Multivariate Analysis
MH  - P-Selectin/blood
MH  - Risk Factors
MH  - Virus Replication/*physiology
PMC - PMC3297698
MID - NIHMS327525
EDAT- 2011/12/06 06:00
MHDA- 2012/06/08 06:00
PMCR- 2013/05/01
CRDT- 2011/12/06 06:00
PHST- 2011/09/13 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/06/08 06:00 [medline]
PHST- 2013/05/01 00:00 [pmc-release]
AID - 10.1111/j.1468-1293.2011.00970.x [doi]
PST - ppublish
SO  - HIV Med. 2012 May;13(5):264-75. doi: 10.1111/j.1468-1293.2011.00970.x. Epub 2011 
      Dec 4.