PMID- 22136715
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20211021
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 33
IP  - 6
DP  - 2012 Feb
TI  - Predicting biomaterial property-dendritic cell phenotype relationships from the 
      multivariate analysis of responses to polymethacrylates.
PG  - 1699-713
LID - 10.1016/j.biomaterials.2011.10.066 [doi]
AB  - Dendritic cells (DCs) play a critical role in orchestrating the host responses to 
      a wide variety of foreign antigens and are essential in maintaining immune 
      tolerance. Distinct biomaterials have been shown to differentially affect the 
      phenotype of DCs, which suggested that biomaterials may be used to modulate 
      immune response toward the biologic component in combination products. The 
      elucidation of biomaterial property-DC phenotype relationships is expected to 
      inform rational design of immuno-modulatory biomaterials. In this study, DC 
      response to a set of 12 polymethacrylates (pMAs) was assessed in terms of surface 
      marker expression and cytokine profile. Principal component analysis (PCA) 
      determined that surface carbon correlated with enhanced DC maturation, while 
      surface oxygen was associated with an immature DC phenotype. Partial square 
      linear regression, a multivariate modeling approach, was implemented and 
      successfully predicted biomaterial-induced DC phenotype in terms of surface 
      marker expression from biomaterial properties with R(prediction)(2) = 0.76. 
      Furthermore, prediction of DC phenotype was effective based on only theoretical 
      chemical composition of the bulk polymers with R(prediction)(2) = 0.80. These 
      results demonstrated that immune cell response can be predicted from biomaterial 
      properties, and computational models will expedite future biomaterial design and 
      selection.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Kou, Peng Meng
AU  - Kou PM
AD  - Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory 
      University, Georgia Institute of Technology, Atlanta, GA 30332, USA.
FAU - Pallassana, Narayanan
AU  - Pallassana N
FAU - Bowden, Rebeca
AU  - Bowden R
FAU - Cunningham, Barry
AU  - Cunningham B
FAU - Joy, Abraham
AU  - Joy A
FAU - Kohn, Joachim
AU  - Kohn J
FAU - Babensee, Julia E
AU  - Babensee JE
LA  - eng
GR  - R01 EB004633-02/EB/NIBIB NIH HHS/United States
GR  - P41 EB001046/EB/NIBIB NIH HHS/United States
GR  - EB001046/EB/NIBIB NIH HHS/United States
GR  - R01 EB004633-01A1/EB/NIBIB NIH HHS/United States
GR  - R01 EB004633-04/EB/NIBIB NIH HHS/United States
GR  - EB004633/EB/NIBIB NIH HHS/United States
GR  - R01 EB004633/EB/NIBIB NIH HHS/United States
GR  - R01 EB004633-03/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111201
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Biocompatible Materials)
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Polymers)
RN  - 0 (Polymethacrylic Acids)
RN  - 059QF0KO0R (Water)
RN  - 25087-26-7 (polymethacrylic acid)
SB  - IM
MH  - Biocompatible Materials/*chemistry
MH  - Coated Materials, Biocompatible/*chemistry
MH  - Combinatorial Chemistry Techniques
MH  - Dendritic Cells/*cytology
MH  - Humans
MH  - Kinetics
MH  - Materials Testing
MH  - Models, Chemical
MH  - Multivariate Analysis
MH  - Phenotype
MH  - Polymers/chemistry
MH  - Polymethacrylic Acids/*chemistry
MH  - Principal Component Analysis
MH  - Regression Analysis
MH  - Surface Properties
MH  - Temperature
MH  - Water/chemistry
PMC - PMC3399429
MID - NIHMS337410
EDAT- 2011/12/06 06:00
MHDA- 2012/04/20 06:00
PMCR- 2013/02/01
CRDT- 2011/12/06 06:00
PHST- 2011/09/29 00:00 [received]
PHST- 2011/10/24 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
PHST- 2013/02/01 00:00 [pmc-release]
AID - S0142-9612(11)01282-8 [pii]
AID - 10.1016/j.biomaterials.2011.10.066 [doi]
PST - ppublish
SO  - Biomaterials. 2012 Feb;33(6):1699-713. doi: 10.1016/j.biomaterials.2011.10.066. 
      Epub 2011 Dec 1.