PMID- 22136911
OWN - NLM
STAT- MEDLINE
DCOM- 20120620
LR  - 20220408
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 61
IP  - 5
DP  - 2012 May
TI  - Effects of weight loss and exercise on chemerin serum concentrations and adipose 
      tissue expression in human obesity.
PG  - 706-14
LID - 10.1016/j.metabol.2011.10.008 [doi]
AB  - Chemerin is a chemoattractant adipokine that regulates adipogenesis and may 
      induce insulin resistance. Chemerin serum concentrations are elevated in obese, 
      insulin-resistant, and inflammatory states in vivo. Here we investigate the role 
      of omental (OM) and subcutaneous (SC) adipose tissue chemerin and CMKLR1 
      messenger RNA (mRNA) expression in human obesity. In addition, we test the 
      hypothesis that changes in chemerin serum concentrations are primarily associated 
      with reduced body fat mass in the context of 3 weight loss intervention studies. 
      Chemerin serum concentration was measured in 740 individuals in a cross-sectional 
      (n = 629) study including a subgroup (n = 161) for which OM and SC chemerin mRNA 
      expression has been analyzed as well as in 3 interventions including 12 weeks of 
      exercise (n = 60), 6 months of calorie-restricted diet (n = 19) studies, and 12 
      months after bariatric surgery (n = 32). Chemerin mRNA is significantly higher 
      expressed in adipose tissue of patients with type 2 diabetes mellitus and 
      correlates with circulating chemerin, body mass index (BMI), percentage body fat, 
      C-reactive protein, homeostasis model assessment of insulin resistance, and 
      glucose infusion rate in euglycemic-hyperinsulinemic clamps. CMKLR1 mRNA 
      expression was not significantly different between the 2 fat depots. Obesity 
      surgery-induced weight loss causes a significant reduction on both OM and SC 
      chemerin expression. All interventions led to significantly reduced chemerin 
      serum concentrations. Decreased chemerin serum concentrations significantly 
      correlate with improved glucose infusion rate and reduced C-reactive protein 
      levels independently of changes in BMI. Insulin resistance and inflammation are 
      BMI-independent predictors of elevated chemerin serum concentrations. Reduced 
      chemerin expression and serum concentration may contribute to improved insulin 
      sensitivity and subclinical inflammation beyond significant weight loss.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Chakaroun, Rima
AU  - Chakaroun R
AD  - Department of Medicine, University of Leipzig, 04103 Leipzig, Germany.
FAU - Raschpichler, Matthias
AU  - Raschpichler M
FAU - Kloting, Nora
AU  - Kloting N
FAU - Oberbach, Andreas
AU  - Oberbach A
FAU - Flehmig, Gesine
AU  - Flehmig G
FAU - Kern, Matthias
AU  - Kern M
FAU - Schon, Michael R
AU  - Schon MR
FAU - Shang, Edward
AU  - Shang E
FAU - Lohmann, Tobias
AU  - Lohmann T
FAU - Dressler, Miriam
AU  - Dressler M
FAU - Fasshauer, Mathias
AU  - Fasshauer M
FAU - Stumvoll, Michael
AU  - Stumvoll M
FAU - Bluher, Matthias
AU  - Bluher M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111202
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (CMKLR1 protein, human)
RN  - 0 (Chemokines)
RN  - 0 (Insulin)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (RARRES2 protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bariatric Surgery
MH  - Body Composition/physiology
MH  - Chemokines/*biosynthesis/blood
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/blood
MH  - Diet, Reducing
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Intercellular Signaling Peptides and Proteins
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood/diet therapy/surgery
MH  - Omentum/metabolism
MH  - RNA, Messenger/biosynthesis
MH  - Receptors, Chemokine/biosynthesis/genetics
MH  - Regression Analysis
MH  - Waist Circumference
MH  - Weight Loss/*physiology
MH  - Young Adult
EDAT- 2011/12/06 06:00
MHDA- 2012/06/21 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/07/20 00:00 [received]
PHST- 2011/10/05 00:00 [revised]
PHST- 2011/10/13 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/06/21 06:00 [medline]
AID - S0026-0495(11)00347-7 [pii]
AID - 10.1016/j.metabol.2011.10.008 [doi]
PST - ppublish
SO  - Metabolism. 2012 May;61(5):706-14. doi: 10.1016/j.metabol.2011.10.008. Epub 2011 
      Dec 2.