PMID- 22137127
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20240109
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 33
IP  - 6
DP  - 2012 Feb
TI  - Single walled carbon nanotubes as drug delivery vehicles: targeting doxorubicin 
      to tumors.
PG  - 1689-98
LID - 10.1016/j.biomaterials.2011.11.004 [doi]
AB  - Single walled carbon nanotubes (SWNTs) are emerging as promising delivery 
      vehicles for cancer diagnostics and chemotherapies due to their unique 
      properties, including, remarkable cell membrane penetrability, high drug-carrying 
      capacities, pH-dependent therapeutic unloading, prolonged circulating times and 
      intrinsic fluorescent, photothermal, photoacoustic and Raman properties. In this 
      leading opinion paper, we systemically discuss and evaluate the relationship of 
      the biological safety of SWNTs with their physicochemical properties such as 
      their length, purity, agglomeration state, concentration and surface 
      functionalization. Other relevant issues, including the cellular uptake 
      mechanism, biodistribution and metabolism of SWNTs are also reviewed. The design 
      and preparation of SWNT-based drug delivery systems (DDSs) and their 
      pharmacokinetic, cancer targeting and therapeutic properties both in vitro and 
      in vivo are highlighted. Future opportunities and challenges of SWNT-based DDSs 
      are also discussed.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Meng, Lingjie
AU  - Meng L
AD  - Department of Polymer Science and Engineering, School of Chemistry and Chemical 
      Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.
FAU - Zhang, Xiaoke
AU  - Zhang X
FAU - Lu, Qinghua
AU  - Lu Q
FAU - Fei, Zhaofu
AU  - Fei Z
FAU - Dyson, Paul J
AU  - Dyson PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111202
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Drug Carriers)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Nanotubes, Carbon)
RN  - 0 (Polysaccharides)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Acoustics
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Doxorubicin/*administration & dosage
MH  - Drug Carriers
MH  - Drug Delivery Systems
MH  - Fluorescent Dyes/chemistry
MH  - HeLa Cells
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Materials Testing
MH  - Nanotechnology/*methods
MH  - Nanotubes, Carbon/*chemistry
MH  - Polysaccharides/chemistry
MH  - Semiconductors
MH  - Spectrum Analysis, Raman/methods
MH  - Surface Properties
EDAT- 2011/12/06 06:00
MHDA- 2012/04/20 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/10/24 00:00 [received]
PHST- 2011/11/03 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
AID - S0142-9612(11)01342-1 [pii]
AID - 10.1016/j.biomaterials.2011.11.004 [doi]
PST - ppublish
SO  - Biomaterials. 2012 Feb;33(6):1689-98. doi: 10.1016/j.biomaterials.2011.11.004. 
      Epub 2011 Dec 2.