PMID- 22137484
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20111205
IS  - 2210-7762 (Print)
VI  - 204
IP  - 10
DP  - 2011 Oct
TI  - High resolution genomic profiling and classical cytogenetics in a group of benign 
      and atypical meningiomas.
PG  - 541-9
LID - 10.1016/j.cancergen.2011.10.007 [doi]
AB  - Meningiomas are classified as benign, atypical, or anaplastic. The majority are 
      sporadic, solitary, and benign tumors with favorable prognoses. However, the 
      prognosis for patients with anaplastic meningiomas remains less favorable. High 
      resolution genomic profiling has the capacity to provide more detailed 
      information. Therefore, we analyzed genomic aberrations of benign and atypical 
      meningiomas using single nucleotide polymorphism (SNP) array, combined with 
      G-banding by trypsin using Giemsa stain (GTG banding), spectral karyotyping, and 
      locus-specific fluorescence in situ hybridization (FISH). We confirmed frequently 
      detected chromosomal aberrations in meningiomas and identified novel genetic 
      events. Applying SNP array, we identified constitutional de novo loss or gain 
      within chromosome 22 in three patients, possibly representing inherited 
      causal events for meningioma formation. We show evidence for somatic segmental 
      uniparental disomy in regions 4p16.1, 7q31.2, 8p23.2, and 9p22.1 not previously 
      described for primary meningioma. GTG-banding and spectral karyotyping detected a 
      novel balanced reciprocal translocation t(4;10)(q12;q26) in one benign 
      meningioma. A paracentric inversion within 1p36, previously described as novel, 
      was detected as a recurrent chromosomal aberration in benign and atypical 
      meningiomas. Analyses of tumors and matched normal tissues with a combination of 
      SNP arrays and complementary techniques will help to further elucidate 
      potentially causal genetic events for tumorigenesis of meningioma.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Holland, Heidrun
AU  - Holland H
AD  - Translational Centre for Regenerative Medicine (TRM), Department of Neurosurgery, 
      University of Leipzig, Leipzig, Germany.
FAU - Mocker, Kristin
AU  - Mocker K
FAU - Ahnert, Peter
AU  - Ahnert P
FAU - Kirsten, Holger
AU  - Kirsten H
FAU - Hantmann, Helene
AU  - Hantmann H
FAU - Koschny, Ronald
AU  - Koschny R
FAU - Bauer, Manfred
AU  - Bauer M
FAU - Schober, Ralf
AU  - Schober R
FAU - Scholz, Markus
AU  - Scholz M
FAU - Meixensberger, Jurgen
AU  - Meixensberger J
FAU - Krupp, Wolfgang
AU  - Krupp W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet
JT  - Cancer genetics
JID - 101539150
SB  - IM
MH  - Aged
MH  - Chromosome Aberrations
MH  - Female
MH  - Genomics/*methods
MH  - Humans
MH  - Male
MH  - Meningeal Neoplasms/*genetics/pathology/surgery
MH  - Meningioma/*genetics/pathology/surgery
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
EDAT- 2011/12/06 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/12/06 06:00
PHST- 2010/12/07 00:00 [received]
PHST- 2011/10/12 00:00 [revised]
PHST- 2011/10/17 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - S2210-7762(11)00300-0 [pii]
AID - 10.1016/j.cancergen.2011.10.007 [doi]
PST - ppublish
SO  - Cancer Genet. 2011 Oct;204(10):541-9. doi: 10.1016/j.cancergen.2011.10.007.