PMID- 22138970
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20221207
IS  - 1708-8267 (Electronic)
IS  - 1081-5589 (Linking)
VI  - 60
IP  - 1
DP  - 2012 Jan
TI  - G1359A polymorphism in the cannabinoid receptor-1 gene is associated with the 
      presence of coronary artery disease in patients with type 2 diabetes.
PG  - 44-8
LID - 10.2310/JIM.0b013e31823d79a4 [doi]
AB  - OBJECTIVE: Previous studies demonstrated that G1359A polymorphism of cannabinoid 
      receptor-1 (CNR1) was associated with cardiovascular risk factors including 
      obesity, insulin resistance, dyslipidemia, and inflammation, which are also risk 
      factors for developing type 2 diabetes mellitus (T2DM). Therefore, this study was 
      aimed to determine whether G1359A polymorphism of CNR1 is associated with T2DM 
      and the presence of coronary artery disease (CAD) in patients with T2DM. METHODS: 
      A total of 450 patients with T2DM (259 patients with CAD and 191 patients without 
      CAD) and 94 healthy subjects were genotyped using polymerase chain reaction and 
      restriction fragment length polymorphism method. RESULTS: No significant 
      differences in genotype frequency of CNR1 were found between normal controls and 
      patients with T2DM without CAD. GG genotype frequency of CNR1 was significantly 
      higher in the patients with T2DM with CAD compared with those without CAD and 
      healthy subjects (P = 0.003 and P = 0.005, respectively). Unconditional logistic 
      regression analysis revealed that GG genotype was significantly associated with 
      the presence of CAD in the patients with T2DM compared with GA and AA genotypes 
      (odds ratio, 2.632; 95% confidence interval, 1.481-4.678; P < 0.001). In 
      addition, GG genotype of CNR1 was significantly correlated with elevated levels 
      of body mass index, systolic blood pressure, homeostasis model assessment of 
      insulin resistance, and C-reactive protein, as well as decreased levels of 
      high-density lipoprotein cholesterol in patients with T2DM. CONCLUSIONS: G1359A 
      polymorphism of CNR1 may be not associated with T2DM but may contribute to the 
      genetic risk for the presence of CAD in patients with T2DM of Chinese Han 
      population.
FAU - Wang, Rui
AU  - Wang R
AD  - Department of Quality Control, Tanggu Blood Center, Tianjin, P.R. China. 
      tjwangrui11@126.com
FAU - Hu, Wenchao
AU  - Hu W
FAU - Qiang, Lu
AU  - Qiang L
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Investig Med
JT  - Journal of investigative medicine : the official publication of the American 
      Federation for Clinical Research
JID - 9501229
RN  - 0 (CNR1 protein, human)
RN  - 0 (Receptor, Cannabinoid, CB1)
SB  - IM
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - China
MH  - Coronary Artery Disease/*complications/*genetics
MH  - Diabetes Mellitus, Type 2/*complications/*genetics
MH  - Ethnicity/genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Receptor, Cannabinoid, CB1/*genetics
EDAT- 2011/12/06 06:00
MHDA- 2013/06/29 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
AID - 10.2310/JIM.0b013e31823d79a4 [doi]
PST - ppublish
SO  - J Investig Med. 2012 Jan;60(1):44-8. doi: 10.2310/JIM.0b013e31823d79a4.