PMID- 22139384
OWN - NLM
STAT- MEDLINE
DCOM- 20120530
LR  - 20211021
IS  - 1791-2431 (Electronic)
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 27
IP  - 4
DP  - 2012 Apr
TI  - miR-24 functions as a tumor suppressor in Hep2 laryngeal carcinoma cells partly 
      through down-regulation of the S100A8 protein.
PG  - 1097-103
LID - 10.3892/or.2011.1571 [doi]
AB  - microRNAs, a family of small non-coding RNAs, regulating approximately 30% of all 
      human genes are deeply involved in the pathogenesis of several types of cancers, 
      including laryngeal squamous cell carcinoma (LSCC). Here, we demonstrate that 
      miR-24 is down-regulated in human LSCC tissues. Ectopic expression of miR-24 in 
      Hep2 cells significantly induced cell morphology changes and inhibited cell 
      proliferation and invasion ability in vitro by targeting S100A8 at the 
      translational level. Meanwhile, miR-24 could significantly inhibit Hep2 cell 
      invasion after S100A8 protein blockade. In conclusion, our results suggest that 
      miR-24 may function as a tumor suppressor in LSCC through down-regulation of 
      S100A8, which suggests that miR-24 could serve as a novel potential maker for 
      LSCC therapy.
FAU - Guo, Yan
AU  - Guo Y
AD  - Department of Medical Genetics, China Medical University, Shenyang 110001, PR 
      China.
FAU - Fu, Weineng
AU  - Fu W
FAU - Chen, Hong
AU  - Chen H
FAU - Shang, Chao
AU  - Shang C
FAU - Zhong, Ming
AU  - Zhong M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111130
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (3' Untranslated Regions)
RN  - 0 (Calgranulin A)
RN  - 0 (MIRN24 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - 3' Untranslated Regions
MH  - Base Sequence
MH  - Calgranulin A/genetics/*metabolism
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/pathology
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Cell Shape
MH  - Down-Regulation
MH  - HEK293 Cells
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/metabolism/pathology
MH  - MicroRNAs/*metabolism
MH  - Molecular Sequence Data
MH  - Neoplasm Invasiveness
MH  - Time Factors
MH  - Transfection
PMC - PMC3583566
EDAT- 2011/12/06 06:00
MHDA- 2012/05/31 06:00
PMCR- 2011/11/30
CRDT- 2011/12/06 06:00
PHST- 2011/10/24 00:00 [received]
PHST- 2011/11/18 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/05/31 06:00 [medline]
PHST- 2011/11/30 00:00 [pmc-release]
AID - or-27-04-1097 [pii]
AID - 10.3892/or.2011.1571 [doi]
PST - ppublish
SO  - Oncol Rep. 2012 Apr;27(4):1097-103. doi: 10.3892/or.2011.1571. Epub 2011 Nov 30.