PMID- 22139453
OWN - NLM
STAT- MEDLINE
DCOM- 20121126
LR  - 20211021
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 221
IP  - 3
DP  - 2012 Jun
TI  - Behavioural and neuroinflammatory effects of the combination of binge ethanol and 
      MDMA in mice.
PG  - 511-25
LID - 10.1007/s00213-011-2598-4 [doi]
AB  - RATIONALE: Binge drinking is a common pattern of alcohol consumption among young 
      people. Binge drinkers are especially susceptible to brain damage when other 
      substances are co-administered, in particular, 3,4-methylendioxymethamphetamine 
      (MDMA). OBJECTIVE: To evaluate the behavioural consequences of voluntary binge 
      ethanol consumption, alone and in combination to MDMA. Also, to elucidate the 
      effects of the combined consumption of these two drugs on neuroinflammation. 
      MATERIALS AND METHODS: Adolescent mice received MDMA (MDMA-treated mice), ethanol 
      (ethanol-treated mice group) or both (ethanol plus MDMA-treated mice). Drinking 
      in the dark (DID) procedure was used as a model of binge. Body temperature, 
      locomotor activity, motor coordination, anxiety-like and despair behaviour in 
      adolescent mice were evaluated 48 h, 72 h, and 7 days after the treatments. Also, 
      neuroinflammatory response to these treatments was measured in the striatum. 
      RESULTS: The hyperthermia observed in MDMA-treated mice was abolished by 
      pre-exposition to ethanol. Ethanol plus MDMA-treated mice showed lower locomotor 
      activity. Ethanol-treated mice showed motor coordination impairment and increased 
      despair behaviour. Anxiety-like behaviour was only seen in animals that were 
      treated with both drugs. Contrarily, neuroinflammation was mostly seen in animals 
      treated only with MDMA. CONCLUSIONS: Ethanol and MDMA co-administration increases 
      the neurobehavioural changes induced by the consumption of each one of these 
      drugs. However, as ethanol consumption did not increase neuroinflammatory 
      responses induced by MDMA, other mechanisms, mediated by ethanol, are likely to 
      account for this effect and need to be evaluated.
FAU - Ros-Simo, Clara
AU  - Ros-Simo C
AD  - Grup de Recerca en Neurobiologia del Comportament, Departament de Ciencies 
      Experimentals i de la Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica 
      de Barcelona, Dr Aiguader 88, 08003 Barcelona, Spain.
FAU - Ruiz-Medina, Jessica
AU  - Ruiz-Medina J
FAU - Valverde, Olga
AU  - Valverde O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111206
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Hallucinogens)
RN  - 3K9958V90M (Ethanol)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Anxiety/chemically induced
MH  - Behavior, Animal/*drug effects
MH  - Body Temperature/drug effects
MH  - Drug Interactions
MH  - Ethanol/administration & dosage/*toxicity
MH  - Hallucinogens/administration & dosage/*toxicity
MH  - Inflammation/chemically induced
MH  - Male
MH  - Mice
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*toxicity
MH  - Neurotoxicity Syndromes/etiology
MH  - Time Factors
EDAT- 2011/12/06 06:00
MHDA- 2012/12/10 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/05/31 00:00 [received]
PHST- 2011/11/21 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1007/s00213-011-2598-4 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2012 Jun;221(3):511-25. doi: 
      10.1007/s00213-011-2598-4. Epub 2011 Dec 6.