PMID- 22139556
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20211021
IS  - 1539-0829 (Electronic)
IS  - 1534-4827 (Linking)
VI  - 12
IP  - 1
DP  - 2012 Feb
TI  - Type 2 diabetes in childhood: clinical characteristics and role of beta-cell 
      autoimmunity.
PG  - 75-81
LID - 10.1007/s11892-011-0247-2 [doi]
AB  - The global obesity epidemic has led to dramatic increases in the incidence and 
      prevalence of type 2 diabetes mellitus (T2DM) among youth worldwide. In today's 
      clinical practice it has become increasingly difficult to distinguish type 1 
      diabetes mellitus (T1DM) from T2DM as many children with T1DM are overweight at 
      diagnosis. Numerous recent publications note a significant proportion of 
      physician-diagnosed T2DM youth with evidence of pancreatic autoimmunity, 
      exemplifying the challenges in distinguishing between T1DM and T2DM. The clinical 
      implications of the phenomenon of antibody positivity in phenotypic T2DM youth, 
      also referred to as "type 1.5 diabetes" (T1.5 DM), "double diabetes," "latent 
      autoimmune diabetes in youth" (LADY), and "hybrid diabetes," are unclear at 
      present. Current and future work should determine if the presence of 
      autoantibodies in phenotypic T2DM youth/children affects clinical course; this 
      will facilitate the development of optimal treatment strategies.
FAU - Badaru, Angela
AU  - Badaru A
AD  - Department of Pediatrics, University of Washington, Seattle, WA, USA. 
      angela.badaru@seattlechildrens.org
FAU - Pihoker, Catherine
AU  - Pihoker C
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Curr Diab Rep
JT  - Current diabetes reports
JID - 101093791
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adolescent
MH  - Age of Onset
MH  - Autoantibodies/*blood
MH  - Biomarkers/blood
MH  - Child
MH  - Diabetes Mellitus, Type 1/*immunology
MH  - Diabetes Mellitus, Type 2/*immunology
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Insulin-Secreting Cells/*immunology/metabolism
MH  - Male
MH  - Obesity/*complications/immunology
MH  - Prevalence
MH  - United States/epidemiology
MH  - Young Adult
EDAT- 2011/12/06 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.1007/s11892-011-0247-2 [doi]
PST - ppublish
SO  - Curr Diab Rep. 2012 Feb;12(1):75-81. doi: 10.1007/s11892-011-0247-2.