PMID- 22141275
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20111206
IS  - 1009-3591 (Print)
IS  - 1009-3591 (Linking)
VI  - 17
IP  - 11
DP  - 2011 Nov
TI  - [Hyperhomocysteinemia and erectile dysfunction: an update].
PG  - 1019-22
AB  - Hyperhomocysteinemia (HHcy) is considered to be one of the most important 
      cardiovascular risk factors. Epidemiological studies conducted on erectile 
      dysfunction (ED) have demonstrated its close correlation with cardiovascular 
      disease, and therefore HHcy might be a novel risk factor of ED. However, the 
      mechanism of ED resulting from HHcy is not precisely known, but may relate to 
      increased damage of vascular endothelial cells, reactive oxygen species (ROS), 
      and atherosclerosis. Although further studies are needed on this association 
      between HHcy and ED, the measurement of plasma Hcy and folic acid levels and 
      molecular analysis of the MTHFR genotype might be added to the ED diagnostic 
      procedure, especially in young patients or in those with a family history of 
      cardiovascular disease. Treatment of ED patients with HHcy should first aim to 
      reduce the Hcy level through administration of folic acid, alone or in 
      combination with vitamin B6 or B12, and then proceed to treatment with PDE5i. 
      This paper offers an overview on the advances in the studies of the correlation 
      between HHcy and ED.
FAU - Wang, Chun-hui
AU  - Wang CH
AD  - Department of Medical Affairs, Nanjing General Hospital of Nanjing Military 
      Region, Nanjing, Jiangsu 210002, China.
FAU - Huang, Yu-feng
AU  - Huang YF
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Zhonghua Nan Ke Xue
JT  - Zhonghua nan ke xue = National journal of andrology
JID - 101093592
SB  - IM
MH  - *Erectile Dysfunction
MH  - Humans
MH  - *Hyperhomocysteinemia
MH  - Male
EDAT- 2011/12/07 06:00
MHDA- 2012/04/20 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nan Ke Xue. 2011 Nov;17(11):1019-22.