PMID- 22142522
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20111206
IS  - 1214-6994 (Print)
IS  - 1214-6994 (Linking)
VI  - 112
IP  - 4
DP  - 2011
TI  - Lack of association between rs1024611 (-2581 A/G) polymorphism in CC-chemokine 
      Ligand 2 and susceptibility to pulmonary Tuberculosis in Zahedan, Southeast Iran.
PG  - 272-8
AB  - Approximately 5-10% of subjects infected with Mycobacterium tuberculosis develop 
      active tuberculosis. It has been proposed that genetic factors determine the 
      host's vulnerability to tuberculosis. Chemokine (C-C motif) ligand 2 (CCL2), 
      commonly known as monocyte chemoattractant protein-1 (MCP-1), plays a key role in 
      protective immunity against M. tuberculosis. The present study was aimed to 
      determine if there was an association between -2581 A/G single nucleotide 
      polymorphism of CCL2 and pulmonary tuberculosis (PTB) in a sample of Iranian 
      subjects. This case-control study was performed on 142 PTB and 166 healthy 
      subjects. The polymorphism of CCL2 (rs1024611) was determined using tetra 
      amplification refractory mutational system-polymerase chain reaction (tetra 
      ARMS-PCR). There were no significant differences between PTB patients and control 
      subjects regarding -2581 A/G single nucleotide polymorphism of CCL2. In 
      conclusion, our results do not support an association of -2581 A/G polymorphism 
      of CCL2 with PTB susceptibility.
FAU - Naderi, M
AU  - Naderi M
AD  - Research Center for Infectious Diseases and Tropical Medicine, Zahedan University 
      of Medical Sciences, Iran.
FAU - Hashemi, M
AU  - Hashemi M
FAU - Karami, H
AU  - Karami H
FAU - Moazeni-Roodi, A
AU  - Moazeni-Roodi A
FAU - Sharifi-Mood, B
AU  - Sharifi-Mood B
FAU - Kouhpayeh, H
AU  - Kouhpayeh H
FAU - Taheri, M
AU  - Taheri M
FAU - Ghavami, S
AU  - Ghavami S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Czech Republic
TA  - Prague Med Rep
JT  - Prague medical report
JID - 101227436
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Tuberculosis, Pulmonary/*genetics
EDAT- 2011/12/07 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - PMR2011A0028 [pii]
PST - ppublish
SO  - Prague Med Rep. 2011;112(4):272-8.