PMID- 22143063
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20171221
IS  - 1526-2359 (Electronic)
IS  - 1073-2748 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - Hematopoietic stem cell allografting for chronic lymphocytic leukemia: a focus on 
      reduced-intensity conditioning regimens.
PG  - 68-75
AB  - BACKGROUND: Allogeneic hematopoietic cell transplantation (allo-HCT) remains the 
      only known treatment modality that currently offers a potential cure to patients 
      with chronic lymphocytic leukemia (CLL). A better understanding of the role of 
      adoptive immunotherapy and its consequent bona fide graft-vs-leukemia (GVL) 
      effect has resulted in a reduction of the ablative intensity and toxicity of 
      preparative allo-HCT regimens. METHODS: The authors review the published data of 
      reduced-intensity conditioning (RIC) allo-HCT in patients with CLL. RESULTS: RIC 
      allo-HCT has reduced the transplant associated morbidity and mortality of the 
      procedure and has consequently broadened applicability of allo-HCT to patients 
      with CLL who are generally of more advanced age (> 60 years) and who often have 
      associated comorbidities. CONCLUSIONS: Published literature supports the use of 
      RIC allo-HCT for these patients once a suitable donor is identified, provided 
      they fulfill acceptable consensus criteria for hematopoietic stem cell 
      allografting. Several studies have shown that T-cell-replete RIC allo-HCT is also 
      capable of overcoming the adverse effect of poor prognostic factors in CLL such 
      as del(17p), unmutated IgVH, or ZAP-70 expression. Continued clinical trials to 
      identify the optimal regimen for RIC allo-HCT for patients with CLL are 
      warranted.
FAU - Kharfan-Dabaja, Mohamed A
AU  - Kharfan-Dabaja MA
AD  - Division of Hematology-Oncology and Bone Marrow Transplantation, Department of 
      Internal Medicine, American University of Beirut, Beirut, Lebanon. 
      MK143@aub.edu.lb
FAU - Bazarbachi, Ali
AU  - Bazarbachi A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer Control
JT  - Cancer control : journal of the Moffitt Cancer Center
JID - 9438457
SB  - IM
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Humans
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/surgery/*therapy
MH  - Prognosis
MH  - Survival Analysis
MH  - Transplantation Conditioning/*methods
MH  - Treatment Outcome
EDAT- 2011/12/07 06:00
MHDA- 2012/06/05 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
AID - 10.1177/107327481201900107 [doi]
PST - ppublish
SO  - Cancer Control. 2012 Jan;19(1):68-75. doi: 10.1177/107327481201900107.