PMID- 2214371
OWN - NLM
STAT- MEDLINE
DCOM- 19901119
LR  - 20190725
IS  - 0021-5198 (Print)
IS  - 0021-5198 (Linking)
VI  - 53
IP  - 4
DP  - 1990 Aug
TI  - Effects of intracerebroventricular administration of magnesium sulphate on blood 
      pressure and heart rate in anesthetized normotensive and hypertensive rats.
PG  - 495-8
AB  - Intracerebroventricular (i.c.v.) injection of magnesium sulphate (MgSO4:2.5, 5 
      and 10 mumol in 5 microliters) decreased blood pressure and heart rate in both 
      anesthetized normotensive (WKY) and hypertensive rats (SHR). The effects were 
      greater in WKY than in SHR. Moreover, a pretreatment with hexamethonium (2 mg/kg, 
      i.v.) significantly blunted the hypotensive and bradycardic effects induced by 
      i.c.v. injection of 10 mumol of MgSO4 in both WKY and SHR. Our data suggest that 
      MgSO4 produces hypotensive and bradycardic effects when injected i.c.v. in both 
      WKY and SHR.
FAU - Squadrito, F
AU  - Squadrito F
AD  - Institute of Pharmacology, Medical School, University of Messina, Italy.
FAU - Buemi, A L
AU  - Buemi AL
FAU - Sturniolo, R
AU  - Sturniolo R
FAU - Buemi, M
AU  - Buemi M
FAU - Corica, F
AU  - Corica F
FAU - Frisina, N
AU  - Frisina N
FAU - Squadrito, G
AU  - Squadrito G
FAU - Caputi, A P
AU  - Caputi AP
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Pharmacol
JT  - Japanese journal of pharmacology
JID - 2983305R
RN  - 7487-88-9 (Magnesium Sulfate)
SB  - IM
MH  - Anesthesia
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Heart Rate/*drug effects
MH  - Hypertension/*physiopathology
MH  - Injections, Intraventricular
MH  - Magnesium Sulfate/administration & dosage/*pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
EDAT- 1990/08/01 00:00
MHDA- 1990/08/01 00:01
CRDT- 1990/08/01 00:00
PHST- 1990/08/01 00:00 [pubmed]
PHST- 1990/08/01 00:01 [medline]
PHST- 1990/08/01 00:00 [entrez]
AID - 10.1254/jjp.53.495 [doi]
PST - ppublish
SO  - Jpn J Pharmacol. 1990 Aug;53(4):495-8. doi: 10.1254/jjp.53.495.