PMID- 22144053
OWN - NLM
STAT- MEDLINE
DCOM- 20120525
LR  - 20160511
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 1
IP  - 6
DP  - 2011 Nov-Dec
TI  - Chronic rhinosinusitis with nasal polyps: elevated serum immunoglobulin E is 
      associated with Staphylococcus aureus on culture.
PG  - 445-50
LID - 10.1002/alr.20079 [doi]
AB  - BACKGROUND: Recent data has implicated Staphylococcus aureus (SA) superantigen as 
      a potential disease modifier in patients with chronic rhinosinusitis (CRS) with 
      nasal polyps (CRSwNP). The objective of this work was to compare total serum 
      immunoglobulin E (IgE) and serum eosinophils in patients with CRSwNP and CRS 
      without nasal polyps (CRSsNP) based on culture results of the 3 most commonly 
      isolated bacteria. METHODS: Retrospective review at a tertiary rhinology referral 
      center of patients with CRS over a 4-year period. RESULTS: Bacterial cultures and 
      immunologic data were obtained from 62 patients with CRSwNP and 34 patients with 
      CRSsNP. SA was the most prevalent bacteria in the CRSwNP group, isolated in 19 
      patients (31%). Patients with elevated total serum IgE (>114 IU/mL) were more 
      likely to have SA on culture (p = 0.04) in this population. The percent serum 
      eosinophil levels in the SA+ group compared with the SA- group was not 
      significant (6.0 vs 5.1, p = 0.17). Lund-Mackay computed tomography (CT) scores, 
      but not Sino-Nasal Outcome Test 20 (SNOT-20) scores were significantly higher in 
      the SA+ vs SA- group (p = 0.03) in patients with CRSwNP. The CRSsNP group 
      demonstrated no difference in IgE or serum eosinophils between different 
      bacterial groups. CONCLUSION: Our findings suggest that there is an association 
      between SA sinonasal presence and elevated total serum IgE in patients with 
      CRSwNP. In addition, SA+ patients had higher Lund-Mackay CT scores, indicating a 
      higher objective burden of disease in this group of patients.
CI  - Copyright (c) 2011 American Rhinologic Society-American Academy of Otolaryngic 
      Allergy, LLC.
FAU - Clark, David W
AU  - Clark DW
AD  - University of Texas Medical School at Houston, Department of 
      Otorhinolaryngology-Head and Neck Surgery and Texas Sinus Institute, Houston, TX 
      77030, USA.
FAU - Wenaas, Ashley
AU  - Wenaas A
FAU - Citardi, Martin J
AU  - Citardi MJ
FAU - Luong, Amber
AU  - Luong A
FAU - Fakhri, Samer
AU  - Fakhri S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110718
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Superantigens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Eosinophils/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Nasal Polyps/complications/*immunology/microbiology
MH  - Pseudomonas aeruginosa/immunology
MH  - Retrospective Studies
MH  - Rhinitis/complications/*immunology/microbiology
MH  - Sinusitis/complications/*immunology/microbiology
MH  - Staphylococcal Infections/complications/*immunology
MH  - Staphylococcus aureus/*immunology
MH  - *Superantigens
EDAT- 2011/12/07 06:00
MHDA- 2012/05/26 06:00
CRDT- 2011/12/07 06:00
PHST- 2010/05/13 00:00 [received]
PHST- 2011/04/05 00:00 [revised]
PHST- 2011/05/24 00:00 [accepted]
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/05/26 06:00 [medline]
AID - 10.1002/alr.20079 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2011 Nov-Dec;1(6):445-50. doi: 10.1002/alr.20079. Epub 
      2011 Jul 18.