PMID- 22145633
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20180816
IS  - 1743-6109 (Electronic)
IS  - 1743-6095 (Linking)
VI  - 9
IP  - 2
DP  - 2012 Feb
TI  - Effects of smoking on plasma testosterone level and erectile function in rats.
PG  - 472-81
LID - 10.1111/j.1743-6109.2011.02555.x [doi]
AB  - INTRODUCTION: There have been several conflicting reports of the effects of 
      smoking on plasma testosterone levels and erectile function in clinical and 
      animal studies. AIM: This study was conducted to determine the actual effects of 
      smoking on plasma testosterone levels and erectile function in rat-smoking 
      models. METHODS: For the exposure to cigarette smoke, the rats in a cage had a 
      constant influx of smoke using a specially constructed device. Twenty-four 
      Sprague Dawley (SD) rats for the acute cigarette exposure were allocated randomly 
      into two groups: an experimental group and a control group. Thirty-six SD rats 
      for the chronic cigarette smoke exposure were randomly divided into three groups: 
      a control group and two experimental groups. MAIN OUTCOME MEASURES: After 
      exposure to smoking, the rats were subjected to electrical field stimulation of 
      the cavernosal nerve to assess the erectile function, and blood was collected to 
      measure the levels of plasma thiocyanate, testosterone, luteinizing hormone, and 
      follicle-stimulating hormone. The histological changes of testes and corpora 
      cavernosum (CC) were examined. RESULTS: In the smoking groups, the thiocyanate 
      levels were significantly higher than in the control group. Also, the mean 
      arterial pressure (MAP) was significantly higher in the smoking groups, but the 
      corpora cavernosal filling rate and maximal intracavernosal pressure/MAP were 
      significantly lower than in the control group. The testosterone levels of 
      experimental groups were significantly lower than those of control group, and the 
      testosterone and thiocyanate levels were significantly correlated with erectile 
      function components in chronic smoking groups. There was no significant 
      histological change in the testes; however, in the CC, there was an increase in 
      collagen fibers and decrease in smooth muscle and sinusoidal space in chronic 
      smoking groups. CONCLUSION: The results suggest that both the vasoconstrictor 
      effects of smoking and the decrease in testosterone levels after chronic smoking 
      had some effects on erectile function in rats.
CI  - (c) 2011 International Society for Sexual Medicine.
FAU - Park, Min Gu
AU  - Park MG
AD  - Department of Urology, Inje University, College of Medicine, Busan, Korea.
FAU - Ko, Ki Won
AU  - Ko KW
FAU - Oh, Mi Mi
AU  - Oh MM
FAU - Bae, Jae Hyun
AU  - Bae JH
FAU - Kim, Je Jong
AU  - Kim JJ
FAU - Moon, Du Geon
AU  - Moon du G
LA  - eng
PT  - Journal Article
DEP - 20111206
PL  - Netherlands
TA  - J Sex Med
JT  - The journal of sexual medicine
JID - 101230693
RN  - 0 (Thiocyanates)
RN  - 3XMK78S47O (Testosterone)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
RN  - O748SU14OM (thiocyanate)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Electric Stimulation
MH  - Erectile Dysfunction/blood/*etiology
MH  - Follicle Stimulating Hormone/blood
MH  - Luteinizing Hormone/blood
MH  - Male
MH  - Penile Erection/*drug effects
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Smoking/*adverse effects
MH  - Testosterone/*blood
MH  - Thiocyanates/blood
EDAT- 2011/12/08 06:00
MHDA- 2013/03/08 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
AID - S1743-6095(15)33876-5 [pii]
AID - 10.1111/j.1743-6109.2011.02555.x [doi]
PST - ppublish
SO  - J Sex Med. 2012 Feb;9(2):472-81. doi: 10.1111/j.1743-6109.2011.02555.x. Epub 2011 
      Dec 6.