PMID- 22147846
OWN - NLM
STAT- MEDLINE
DCOM- 20120725
LR  - 20220316
IS  - 1477-0962 (Electronic)
IS  - 0961-2033 (Linking)
VI  - 21
IP  - 5
DP  - 2012 Apr
TI  - Urinary monocyte chemoattractant protein 1 and alpha 1 acid glycoprotein as 
      biomarkers of renal disease activity in juvenile-onset systemic lupus 
      erythematosus.
PG  - 496-501
LID - 10.1177/0961203311431249 [doi]
AB  - A higher proportion of patients with juvenile-onset systemic lupus erythematosus 
      (JSLE) will have renal involvement compared with adult-onset disease, some 
      progressing to renal failure in adulthood. Histological examination is the gold 
      standard for diagnosing lupus nephritis (LN), but its invasive nature limits 
      routine use. Using cross-sectional cohort analysis, we aimed to determine whether 
      urinary concentrations of monocyte chemoattractant protein-1 (MCP1), alpha-1-acid 
      glycoprotein (AGP) and interferon-inducible protein 10 (IP10) are biomarkers of 
      active LN. Sixty JSLE patients recruited to the UK JSLE Cohort Study were 
      categorized according to the British Isles Lupus Assessment Group (BILAG) 
      activity index. Patients with active renal JSLE (n = 8; renal BILAG score A, B) 
      had significantly higher urinary MCP1 concentrations than patients with inactive 
      renal disease (n = 52; renal BILAG score C, D, E; 582 pg/mg creatinine [Cr], 207 
      pg/mg Cr; p = 0.018) or healthy controls (n = 23; 117 pg/mg Cr; p = 0.005). 
      Urinary AGP concentration was significantly elevated in patients with active 
      renal disease compared with inactive renal disease (1517 ng/mg Cr, 485 ng/mg Cr; 
      p = 0.027) or healthy controls (313 ng/mg Cr; p = 0.013). Urinary IP10 
      concentration was not significantly different between groups, but did strongly 
      correlate with uMCP and uAGP levels (rho = 0.38, p = 0.009; rho = 0.33, 
      p = 0.021). Urinary MCP1 and AGP are biomarkers of LN, providing insight into its 
      pathophysiology. Longitudinal studies are warranted.
FAU - Watson, L
AU  - Watson L
AD  - Department of Women's and Children's Health, University of Liverpool, Liverpool, 
      UK. louise.watson@liv.ac.uk
FAU - Midgley, A
AU  - Midgley A
FAU - Pilkington, C
AU  - Pilkington C
FAU - Tullus, K
AU  - Tullus K
FAU - Marks, Sd
AU  - Marks S
FAU - Holt, Rcl
AU  - Holt R
FAU - Jones, Ca
AU  - Jones C
FAU - Beresford, Mw
AU  - Beresford M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111206
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Orosomucoid)
SB  - IM
MH  - Adolescent
MH  - Age of Onset
MH  - Biomarkers/urine
MH  - Chemokine CCL2/*urine
MH  - Chemokine CXCL10/urine
MH  - Child
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Systemic/physiopathology/*urine
MH  - Lupus Nephritis/physiopathology/*urine
MH  - Male
MH  - Orosomucoid/*urine
MH  - Prospective Studies
MH  - United Kingdom
EDAT- 2011/12/08 06:00
MHDA- 2012/07/26 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/07/26 06:00 [medline]
AID - 0961203311431249 [pii]
AID - 10.1177/0961203311431249 [doi]
PST - ppublish
SO  - Lupus. 2012 Apr;21(5):496-501. doi: 10.1177/0961203311431249. Epub 2011 Dec 6.