PMID- 22148108
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120504
LR  - 20220318
IS  - 2093-0887 (Electronic)
IS  - 2093-0879 (Print)
IS  - 2093-0879 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Oct
TI  - Comparison of clinical characteristics of patients with gastroesophageal reflux 
      disease who failed proton pump inhibitor therapy versus those who fully 
      responded.
PG  - 387-94
LID - 10.5056/jnm.2011.17.4.387 [doi]
AB  - BACKGROUND/AIMS: Refractory gastroesophageal reflux disease (GERD) is very 
      common, affecting up to 40% of the patients receiving proton pump inhibitor (PPI) 
      therapy. However, there is not much information about the clinical 
      characteristics of these patients. The aim of the study is to compare the 
      clinical characteristics of PPI responders vs non-responders. METHODS: 
      Consecutive GERD patients receiving PPI once or twice daily were evaluated by a 
      questionnaire and a personal interview regarding their demographics, habits, 
      clinical characteristics and endoscopic findings. The patients were divided into 
      3 groups: Patients who fully responded to PPI once daily (Group A, n = 111), 
      patients who failed PPI once daily (Group B, n = 78) and patients who failed PPI 
      twice daily (Group C, n = 56). RESULTS: A total of 245 patients (59.3% females, 
      52 +/- 17.2 years of age) were included in this study. Cross-group differences (A 
      vs B vs C) were detected for hiatal hernia (33% vs 51% vs 52%, P = 0.011); 
      erosive esophagitis (19% vs 51% vs 30%, P < 0.0001); cough (24% vs 44% vs 43%, P 
      = 0.007); sleep disturbances (19% vs 30% vs 38%, P = 0.033); chest symptoms (21% 
      vs 35% vs 41%, P = 0.010); Helicobacter pylori status (25% vs 33% vs 48%, P < 
      0.0001), disease duration (1.6 +/- 0.8 vs 1.9 +/- 1.0 vs 2.0 +/- 1.1 years, P = 0.007), 
      performed lifestyle interventions (68.5% vs 46.7% vs 69.6%, P = 0.043) and 
      compliance (84% vs 55% vs 46%, P < 0.0001). CONCLUSIONS: PPI failure (either once 
      or twice daily) appears to be significantly associated with atypical GERD 
      symptoms, disease duration and severity, H. pylori status, obesity, performed 
      lifestyle interventions and compliance as compared with PPI responders.
FAU - Dickman, Ram
AU  - Dickman R
AD  - Department of Gastroenterology, Rabin Medical Center, Beilinson Hospital, Petach 
      Tikva, Israel. dickmanrw@hotmail.com
FAU - Boaz, Mona
AU  - Boaz M
FAU - Aizic, Shoshanna
AU  - Aizic S
FAU - Beniashvili, Zaza
AU  - Beniashvili Z
FAU - Fass, Ronnie
AU  - Fass R
FAU - Niv, Yaron
AU  - Niv Y
LA  - eng
PT  - Journal Article
DEP - 20111031
PL  - Korea (South)
TA  - J Neurogastroenterol Motil
JT  - Journal of neurogastroenterology and motility
JID - 101530189
PMC - PMC3228979
OTO - NOTNLM
OT  - Compliance
OT  - Gastroesophageal reflux
OT  - Proton pump inhibitors
COIS- Conflicts of interest: None.
EDAT- 2011/12/08 06:00
MHDA- 2011/12/08 06:01
PMCR- 2011/10/01
CRDT- 2011/12/08 06:00
PHST- 2011/06/22 00:00 [received]
PHST- 2011/07/19 00:00 [revised]
PHST- 2011/07/28 00:00 [accepted]
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2011/12/08 06:01 [medline]
PHST- 2011/10/01 00:00 [pmc-release]
AID - 10.5056/jnm.2011.17.4.387 [doi]
PST - ppublish
SO  - J Neurogastroenterol Motil. 2011 Oct;17(4):387-94. doi: 
      10.5056/jnm.2011.17.4.387. Epub 2011 Oct 31.