PMID- 22148923
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20120110
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 28
IP  - 1
DP  - 2012 Jan 10
TI  - Direct visualization of bactericidal action of cationic conjugated 
      polyelectrolytes and oligomers.
PG  - 65-70
LID - 10.1021/la2044569 [doi]
AB  - The bactericidal mechanisms of poly(phenylene ethynylene) (PPE)-based cationic 
      conjugated polyelectrolytes (CPE) and oligo-phenylene ethynylenes (OPE) were 
      investigated using electron/optical microscopy and small-angle X-ray scattering 
      (SAXS). The ultrastructural analysis shows that polymeric PPE-Th can 
      significantly remodel the bacterial outer membrane and/or the peptidoglycan 
      layer, followed by the possible collapse of the bacterial cytoplasm membrane. In 
      contrast, oligomeric end-only OPE (EO-OPE) possesses potent bacteriolysis 
      activity, which efficiently disintegrates the bacterial cytoplasm membrane and 
      induces the release of bacterial cell content. Using single giant vesicles and 
      SAXS, we demonstrated that the membrane perturbation mechanism of EO-OPE against 
      model bacterial membranes results from a 3D membrane phase transition or 
      perturbation.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Chemical and Nuclear Engineering, Center for Biomedical 
      Engineering, University of New Mexico, Albuquerque, New Mexico 87131-1341, United 
      States.
FAU - Corbitt, Thomas S
AU  - Corbitt TS
FAU - Jett, Stephen D
AU  - Jett SD
FAU - Tang, Yanli
AU  - Tang Y
FAU - Schanze, Kirk S
AU  - Schanze KS
FAU - Chi, Eva Y
AU  - Chi EY
FAU - Whitten, David G
AU  - Whitten DG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111216
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
RN  - 0 (Cations)
RN  - 0 (Electrolytes)
RN  - 0 (Polymers)
SB  - IM
MH  - Bacteria/*drug effects
MH  - Cations
MH  - Electrolytes/*pharmacology
MH  - Escherichia coli/drug effects
MH  - Microscopy, Electron, Scanning
MH  - Microscopy, Electron, Transmission
MH  - Polymers/*pharmacology
MH  - Scattering, Radiation
EDAT- 2011/12/14 06:00
MHDA- 2012/04/26 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
AID - 10.1021/la2044569 [doi]
PST - ppublish
SO  - Langmuir. 2012 Jan 10;28(1):65-70. doi: 10.1021/la2044569. Epub 2011 Dec 16.