PMID- 22149342
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20211021
IS  - 1744-8409 (Electronic)
IS  - 1744-666X (Print)
IS  - 1744-666X (Linking)
VI  - 8
IP  - 1
DP  - 2012 Jan
TI  - Dendritic cells and aging: consequences for autoimmunity.
PG  - 73-80
LID - 10.1586/eci.11.77 [doi]
AB  - The immune system has evolved to mount immune responses against foreign pathogens 
      and to remain silent against self-antigens. A balance between immunity and 
      tolerance is required as any disturbance may result in chronic inflammation or 
      autoimmunity. Dendritic cells (DCs) actively participate in maintaining this 
      balance. Under steady-state conditions, DCs remain in an immature state and do 
      not mount an immune response against circulating self-antigens in the periphery, 
      which maintains a state of tolerance. By contrast, foreign antigens result in DC 
      maturation and DC-induced T-cell activation. Inappropriate maturation of DCs due 
      to infections or tissue injury may cause alterations in the balance between the 
      tolerogenic and immunogenic functions of DCs and instigate the development of 
      autoimmune diseases. This article provides an overview of the effects of 
      advancing age on DC functions and their implications in autoimmunity.
FAU - Agrawal, Anshu
AU  - Agrawal A
AD  - Division of Basic and Clinical Immunology, Department of Medicine, University of 
      California, Irvine, CA 92697, USA. aagrawal@uci.edu
FAU - Sridharan, Aishwarya
AU  - Sridharan A
FAU - Prakash, Sangeetha
AU  - Prakash S
FAU - Agrawal, Harsh
AU  - Agrawal H
LA  - eng
GR  - R21 AG027512/AG/NIA NIH HHS/United States
GR  - R21 AG027512-01A1/AG/NIA NIH HHS/United States
GR  - R21 AG027512-02/AG/NIA NIH HHS/United States
GR  - AG027512/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Expert Rev Clin Immunol
JT  - Expert review of clinical immunology
JID - 101271248
RN  - 0 (Autoantigens)
SB  - IM
MH  - Aging/*immunology/pathology
MH  - Autoantigens/immunology
MH  - Autoimmune Diseases/*immunology/pathology
MH  - *Autoimmunity
MH  - Dendritic Cells/*immunology/pathology
MH  - Humans
MH  - Inflammation/immunology/pathology
MH  - Lymphocyte Activation/immunology
MH  - T-Lymphocytes/immunology/pathology
PMC - PMC3285507
MID - NIHMS357114
EDAT- 2011/12/14 06:00
MHDA- 2012/04/04 06:00
PMCR- 2012/11/01
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
PHST- 2012/11/01 00:00 [pmc-release]
AID - 10.1586/eci.11.77 [doi]
PST - ppublish
SO  - Expert Rev Clin Immunol. 2012 Jan;8(1):73-80. doi: 10.1586/eci.11.77.