PMID- 22149670
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20111214
IS  - 1361-6536 (Electronic)
IS  - 0954-898X (Linking)
VI  - 22
IP  - 1-4
DP  - 2011
TI  - A unified description of cerebellar inter-spike interval distributions and 
      variabilities using summation of Gaussians.
PG  - 74-96
LID - 10.3109/0954898X.2011.636860 [doi]
AB  - Neuronal inter-spike intervals (ISIs) have previously been described as Poisson, 
      Gamma, inverse Gaussian or other unimodal distributions. We analyzed ISIs of 
      rhythmic and arrhythmic neuronal spike trains in cerebellum recorded from freely 
      behaving rats, and found that their distributions can be described as the 
      summation or integration of multiple Gaussian distributions. The ISIs of rhythmic 
      cerebellar Purkinje cells have a main Gaussian peak at a basic firing interval 
      and exponentially reduced peaks at multiples of this firing period. ISIs of 
      arrhythmic Purkinje cells can be modeled as the integration of multiple Gaussian 
      distributions centered at continuous intervals with exponentially reduced peak 
      amplitudes. The sources of variability are directly related to the relative 
      timing of action potentials between neighboring cells since we show that 
      irregularities of discharge in one cell are associated with the previous history 
      of its discharge in time relative to another cell. Through relative phase 
      analyses, we demonstrate that the shape and the mathematical form of the ISI 
      distributions in cerebellum are direct result of dynamic interactions in the 
      nearby neuronal network, in addition to intrinsic firing properties. The analysis 
      in this paper provides a unified description of cerebellar inter-spike interval 
      distributions which deviate from the usual Poisson assumptions. Our results 
      suggest the existence of an intrinsic rhythmicity in cells exhibiting arrhythmic 
      spike trains in cerebellum, and may identify an important source of variability 
      in neuronal firing patterns that is relevant to the mechanism of neural 
      computation in cerebellum.
FAU - Chen, Yanqing
AU  - Chen Y
AD  - The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, 
      USA. ychen@nsi.edu
FAU - Nitz, Douglas A
AU  - Nitz DA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Network
JT  - Network (Bristol, England)
JID - 9431867
SB  - IM
MH  - *Action Potentials/physiology
MH  - Animals
MH  - *Cerebellum/physiology
MH  - *Models, Neurological
MH  - Normal Distribution
MH  - Periodicity
MH  - Purkinje Cells/physiology
MH  - Rats
MH  - Time Factors
EDAT- 2011/12/14 06:00
MHDA- 2012/08/21 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - 10.3109/0954898X.2011.636860 [doi]
PST - ppublish
SO  - Network. 2011;22(1-4):74-96. doi: 10.3109/0954898X.2011.636860.