PMID- 22152396
OWN - NLM
STAT- MEDLINE
DCOM- 20130717
LR  - 20131121
IS  - 1475-2697 (Electronic)
IS  - 0022-149X (Linking)
VI  - 87
IP  - 1
DP  - 2013 Mar
TI  - The use of albendazole and diammonium glycyrrhizinate in the treatment of 
      eosinophilic meningitis in mice infected with Angiostrongylus cantonensis.
PG  - 1-11
LID - 10.1017/S0022149X11000745 [doi]
AB  - Angiostrongylus cantonensis (A. cantonensis) infection causes eosinophilic 
      meningitis in humans. Eosinophilia and a Th2-type immune response are the crucial 
      immune mechanisms for eosinophilic meningitis. CD4+CD25+ regulatory T cells 
      (Treg) are involved in the pathogenesis of A. cantonensis. Diammonium 
      glycyrrhizinate (DG) is a compound related to glycyrrhizin (GL), a triterpene 
      glycoside extracted from liquorice root. We investigated the curative effects and 
      probable mechanisms of therapy involving a combination of albendazole and DG in 
      BALB/c mice infected with A. cantonensis, and compared these with therapy 
      involving albendazole and dexamethasone. We analysed survival time, body weight, 
      signs, eosinophil numbers, immunoglobulin E (IgE), interleukin-5 (IL-5), and 
      eotaxin concentrations, numbers and Foxp3 expression of CD4+CD25+ Treg, worm 
      recovery and histopathology. The present results demonstrated that the 
      combination of albendazole and DG could increase survival time more efficiently 
      and relieve neurological dysfunction; decrease weight loss, eosinophil numbers, 
      concentrations of IgE, IL-5 and eotaxin, the number and expression of Foxp3 of 
      CD4+CD25+ Treg; and improve worm recovery and histopathology changes in treated 
      animals, compared with the combination of albendazole and dexamethasone. The 
      observations presented here suggest that the albendazole and dexamethasone 
      combination could be replaced by the combination of albendazole and DG.
FAU - Li, Y
AU  - Li Y
AD  - Department of Biopharmaceuticals, School of Biotechnology, Southern Medical 
      University, Guangzhou 510515, Guangdong, People's Republic of China.
FAU - Tang, J-P
AU  - Tang JP
FAU - Chen, D-R
AU  - Chen DR
FAU - Fu, C-Y
AU  - Fu CY
FAU - Wang, P
AU  - Wang P
FAU - Li, Z
AU  - Li Z
FAU - Wei, W
AU  - Wei W
FAU - Li, H
AU  - Li H
FAU - Dong, W-Q
AU  - Dong WQ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111213
PL  - England
TA  - J Helminthol
JT  - Journal of helminthology
JID - 2985115R
RN  - 0 (Anthelmintics)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 6FO62043WK (Glycyrrhizic Acid)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - F4216019LN (Albendazole)
SB  - IM
MH  - Albendazole/*administration & dosage
MH  - Angiostrongylus cantonensis/*drug effects/pathogenicity
MH  - Animals
MH  - Anthelmintics/*administration & dosage
MH  - Body Weight
MH  - Dexamethasone/administration & dosage
MH  - Disease Models, Animal
MH  - Eosinophilia/*drug therapy/parasitology
MH  - Female
MH  - Glycyrrhizic Acid/*administration & dosage
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Leukocyte Count
MH  - Meningitis/*drug therapy/parasitology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Strongylida Infections/*drug therapy/parasitology
MH  - Survival Analysis
MH  - T-Lymphocytes, Regulatory/immunology
MH  - Treatment Outcome
EDAT- 2011/12/14 06:00
MHDA- 2013/07/19 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2013/07/19 06:00 [medline]
AID - S0022149X11000745 [pii]
AID - 10.1017/S0022149X11000745 [doi]
PST - ppublish
SO  - J Helminthol. 2013 Mar;87(1):1-11. doi: 10.1017/S0022149X11000745. Epub 2011 Dec 
      13.