PMID- 22153485
OWN - NLM
STAT- MEDLINE
DCOM- 20120828
LR  - 20120127
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 86
IP  - 7
DP  - 2012 Feb
TI  - A rapid method for screening of the Stockholm Convention POPs in small amounts of 
      human plasma using SPE and HRGC/HRMS.
PG  - 747-53
LID - 10.1016/j.chemosphere.2011.11.006 [doi]
AB  - A rapid analytical screening method allowing simultaneous analysis of 23 
      persistent organic pollutants (POPs) in human plasma was developed. Sample 
      preparation based on solid-phase extraction (SPE) with additional clean-up using 
      small multilayer silica gel columns. SPE was performed using a custom made 
      polystyrene-divinylbenzene sorbent for the extraction of chlorinated and 
      brominated POPs. Special efforts to reduce sample volume and improve speed and 
      efficiency of the analytical procedure were made. Determination of 16 
      polychlorinated biphenyls (PCBs), 5 organochlorine (OC) pesticides, 
      octachlorinated dibenzo-p-dioxin (OCDD) and polybrominated diphenyl ether (BDE 
      #47) in 0.5 mL human plasma was performed by using high resolution gas 
      chromatography coupled to high resolution mass spectrometry (HRGC/HRMS). Recovery 
      of POPs ranged between 46% and 110%, and reproducibility was below 25% relative 
      standard deviation (RSD) for all target compounds, except for trans-nonachlor and 
      OCDD, which were present only at low levels. Limits of detection (LOD) were for 
      the PCBs between 0.8 and 117.7 pg mL(-1) plasma and for the OC pesticides between 
      5.9 and 89.1 pg mL(-1) plasma. The LOD for OCDD and BDE #47 were 1.4 pg mL(-1) 
      plasma, and 9.2 pg mL(-1) plasma, respectively. The presented method was 
      successfully applied to 1016 human plasma samples from an epidemiological study 
      on cardiovascular disease.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Salihovic, Samira
AU  - Salihovic S
AD  - MTM Research Centre, School of Science and Technology, Orebro University, SE-701 
      82 Orebro, Sweden. samira.salihovic@oru.se
FAU - Mattioli, Lisa
AU  - Mattioli L
FAU - Lindstrom, Gunilla
AU  - Lindstrom G
FAU - Lind, Lars
AU  - Lind L
FAU - Lind, P Monica
AU  - Lind PM
FAU - van Bavel, Bert
AU  - van Bavel B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111205
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Aged
MH  - Environmental Pollutants/*blood/chemistry/*isolation & purification
MH  - Gas Chromatography-Mass Spectrometry/*methods/standards
MH  - Humans
MH  - Male
MH  - Organic Chemicals/*blood/chemistry/*isolation & purification
MH  - Quality Control
MH  - Solid Phase Extraction/*methods/standards
MH  - Time Factors
EDAT- 2011/12/14 06:00
MHDA- 2012/08/29 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/03/01 00:00 [received]
PHST- 2011/07/26 00:00 [revised]
PHST- 2011/11/06 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/08/29 06:00 [medline]
AID - S0045-6535(11)01258-6 [pii]
AID - 10.1016/j.chemosphere.2011.11.006 [doi]
PST - ppublish
SO  - Chemosphere. 2012 Feb;86(7):747-53. doi: 10.1016/j.chemosphere.2011.11.006. Epub 
      2011 Dec 5.