PMID- 22153644
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20161013
IS  - 1715-3360 (Electronic)
IS  - 0008-4182 (Linking)
VI  - 46
IP  - 6
DP  - 2011 Dec
TI  - Spectral-domain optical coherence tomography for early glaucoma assessment: 
      analysis of macular ganglion cell complex versus peripapillary retinal nerve 
      fiber layer.
PG  - 543-7
LID - 10.1016/j.jcjo.2011.09.006 [doi]
AB  - OBJECTIVE: We sought to compare the glaucoma discrimination ability of macular 
      inner retinal layer (MIRL) thickness with that of conventional peripapillary 
      retinal nerve fiber layer (pRNFL) thickness as measured by spectral-domain 
      optical coherence tomography (SD-OCT) in patients with early glaucoma. DESIGN: 
      Cross-sectional study. PARTICIPANTS: We studied 67 patients with early glaucoma 
      (visual field mean deviation index >/=-6 dB), and 56 healthy subjects were 
      prospectively enrolled. METHODS: All patients underwent MIRL thickness 
      measurement (ganglion cell complex [GCC] scan) and pRNFL thickness measurement 
      (3.45 mm scan) by SD-OCT. Whenever both eyes were eligible, one was randomly 
      selected. Receiver operating characteristic curves and sensitivities at fixed 
      specificities were generated for different parameters. The areas under the 
      receiver operating characteristic curves (AUCs) of each parameter were compared. 
      RESULTS: The average mean deviation for the glaucomatous eyes was -2.5 +/- 1.6 dB. 
      The AUCs for average (0.815); superior (0.807); and inferior (0.788) MIRL 
      thicknesses were not significantly different (p >/= 0.18). The AUCs for average 
      (0.735); superior (0.728); and inferior (0.697) pRNFL thicknesses were also 
      similar (p >/= 0.15). Average MIRL thickness had a significantly larger AUC 
      compared to average pRNFL thickness analysis (0.815 vs 0.735; p = 0.03). 
      Sensitivities at 80% specificity for average MIRL and pRNFL thicknesses were 
      66.7% (cutoff, 89.9 mum) and 62.9% (cutoff, 111.8 mum), respectively. CONCLUSIONS: 
      The GCC scan showed a similar or even a slightly better ability to discriminate 
      between healthy and early glaucomatous eyes compared to the pRNFL scan. Different 
      from previous analyses considering total macular thickness, the GCC macular scan 
      seems to be a useful tool for identification of early structural damage in 
      patients with glaucoma.
CI  - Copyright (c) 2011 Canadian Ophthalmological Society. Published by Elsevier Inc. 
      All rights reserved.
FAU - Moreno, Pilar A M
AU  - Moreno PA
AD  - Hospital Medicina dos Olhos, Sao Paulo, Brazil; Federal University of Sao Paulo, 
      Sao Paulo, Brazil.
FAU - Konno, Bruno
AU  - Konno B
FAU - Lima, Veronica Castro
AU  - Lima VC
FAU - Castro, Dinorah P E
AU  - Castro DP
FAU - Castro, Leonardo Cunha
AU  - Castro LC
FAU - Leite, Mauro Toledo
AU  - Leite MT
FAU - Pacheco, Maria A M Mendes
AU  - Pacheco MA
FAU - Lee, Jae Min
AU  - Lee JM
FAU - Prata, Tiago Santos
AU  - Prata TS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Can J Ophthalmol
JT  - Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
JID - 0045312
SB  - IM
MH  - Axons/*pathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma/*diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*diagnosis
MH  - Prospective Studies
MH  - ROC Curve
MH  - Retinal Ganglion Cells/*pathology
MH  - Sensitivity and Specificity
MH  - *Tomography, Optical Coherence
EDAT- 2011/12/14 06:00
MHDA- 2012/03/31 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/01/17 00:00 [received]
PHST- 2011/05/06 00:00 [revised]
PHST- 2011/06/16 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - S0008-4182(11)00216-X [pii]
AID - 10.1016/j.jcjo.2011.09.006 [doi]
PST - ppublish
SO  - Can J Ophthalmol. 2011 Dec;46(6):543-7. doi: 10.1016/j.jcjo.2011.09.006.