PMID- 22153917
OWN - NLM
STAT- MEDLINE
DCOM- 20120912
LR  - 20121115
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1433
DP  - 2012 Jan 18
TI  - Neuroprotective effects of osthole pretreatment against traumatic brain injury in 
      rats.
PG  - 127-36
LID - 10.1016/j.brainres.2011.11.027 [doi]
AB  - Osthole, a coumarin compound isolated from the plant-derived herb Cnidium 
      monnieri, has been the subject of considerable interest because of its broad 
      spectrum of pharmacological properties. The aim of this study was to investigate 
      the potential protective effects of osthole in adult rats in the setting of 
      traumatic brain injury (TBI). We employed Feeney's weight-drop model to ascertain 
      whether intraperitoneal administration of osthole (10mg/kg, 20mg/kg and 40 mg/kg) 
      30 min before TBI could reduce the severity of neurological deficits, cerebral 
      edema, and hippocampal neuron loss. The levels of malondialdehyde (MDA) and 
      glutathione (GSH), the activity of superoxide dismutase (SOD), the expressions of 
      Bcl-2, Bax, and active caspase-3, and the number of terminal deoxynucleotidyl 
      transferase-mediated dUTP nick end labeling (TUNEL)-positive apoptotic cells were 
      also measured to characterize the antioxidative and antiapoptotic properties. A 
      significant reduction of neurological deficits, cerebral edema and hippocampal 
      neuron loss was observed in the osthole pretreatment groups (20mg/kg and 40 
      mg/kg, but not 10mg/kg) by 24h after TBI compared with the TBI group. 
      Furthermore, pretreatment with osthole (40 mg/kg) significantly increased the 
      activity of SOD, the level of GSH, and the ratio of Bcl-2/Bax, and also reduced 
      the level of MDA, the expression of active caspase-3, and the number of apoptotic 
      cells at 24h after TBI. In summary, these results suggested that osthole had a 
      neuroprotective effect against TBI, and the protection may be associated with its 
      antioxidative and antiapoptotic functions.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - He, Yalong
AU  - He Y
AD  - Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing 
      Hospital, Fourth Military Medical University, No. 127, Changle Western Road, 
      Xi'an, Shanxi 710032, China.
FAU - Qu, Shuoyao
AU  - Qu S
FAU - Wang, Jiang
AU  - Wang J
FAU - He, Xiaosheng
AU  - He X
FAU - Lin, Wei
AU  - Lin W
FAU - Zhen, Haining
AU  - Zhen H
FAU - Zhang, Xiang
AU  - Zhang X
LA  - eng
PT  - Journal Article
DEP - 20111118
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Coumarins)
RN  - 0 (Neuroprotective Agents)
RN  - XH1TI1759C (osthol)
SB  - IM
MH  - Animals
MH  - Brain Injuries/metabolism/*pathology/*prevention & control
MH  - Cnidium/chemistry
MH  - Coumarins/*administration & dosage
MH  - Male
MH  - Neuroprotective Agents/*administration & dosage
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2011/12/14 06:00
MHDA- 2012/09/13 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/05/26 00:00 [received]
PHST- 2011/10/22 00:00 [revised]
PHST- 2011/11/09 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/09/13 06:00 [medline]
AID - S0006-8993(11)02088-9 [pii]
AID - 10.1016/j.brainres.2011.11.027 [doi]
PST - ppublish
SO  - Brain Res. 2012 Jan 18;1433:127-36. doi: 10.1016/j.brainres.2011.11.027. Epub 
      2011 Nov 18.