PMID- 22154247
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20161125
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Linking)
VI  - 106
IP  - 5
DP  - 2012 May
TI  - Influence of inspiration level on bronchial lumen measurements with computed 
      tomography.
PG  - 677-86
LID - 10.1016/j.rmed.2011.11.013 [doi]
AB  - BACKGROUND: Bronchial dimensions measured in CT images generally do not take 
      inspiration level into consideration. However, some studies showed that the 
      bronchial membrane is distensible with airway inflation. Therefore, 
      re-examination of the elasticity of bronchi is needed. PURPOSE: To assess the 
      influence of respiration on bronchial lumen area (defined as distensibility) in 
      different segmental bronchi and to explore the correlations between 
      distensibility and both lung function and emphysema severity. MATERIAL AND 
      METHODS: In 44 subjects with COPD related to alpha-1-antitrypsin deficiency 
      (AATD), bronchial lumen area was measured in CT images, acquired at different 
      inspiration levels. Measurements were done at matched locations in one apical and 
      two basal segmental airways (RB1, RB10 and LB10). Airway distensibility was 
      calculated as lumen area difference divided by lung volume difference. RESULTS: 
      Bronchial lumen area in the lower lobes (RB10 and LB10) correlated positively 
      with FEV(1)%predicted (p=0.027 for RB10; and p=0.037 for LB10, respectively). 
      Lumen area is influenced by respiration (p=0.006, p=0.045, and, p=0.005 for RB1, 
      RB10 and LB10, respectively). Airway distensibility was different between upper 
      and lower bronchi (p<0.001), but it was not correlated with lung function. 
      CONCLUSION: Lumen area of third generation bronchi is dependent on inspiration 
      level and this distensibility is different between bronchi in the upper and lower 
      lobes. Therefore, changes in lumen area over time should be studied whilst 
      accounting for the lung volume changes, in order to estimate the progression of 
      bronchial disease while excluding the effects of hyperinflation.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Bakker, M Els
AU  - Bakker ME
AD  - Division of Image Processing, Department of Radiology, Leiden University Medical 
      Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. m.e.bakker@lumc.nl
FAU - Stolk, Jan
AU  - Stolk J
FAU - Reiber, Johan H C
AU  - Reiber JH
FAU - Stoel, Berend C
AU  - Stoel BC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111205
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
SB  - IM
MH  - Adult
MH  - Bronchi/*pathology/physiopathology
MH  - Bronchography/methods
MH  - Female
MH  - Humans
MH  - Inhalation/*physiology
MH  - Male
MH  - Middle Aged
MH  - Phantoms, Imaging
MH  - Pulmonary Disease, Chronic Obstructive/*diagnostic 
      imaging/etiology/pathology/physiopathology
MH  - Reproducibility of Results
MH  - Respiratory Mechanics/physiology
MH  - Tomography, X-Ray Computed/methods
MH  - alpha 1-Antitrypsin Deficiency/complications
EDAT- 2011/12/14 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/04/26 00:00 [received]
PHST- 2011/11/14 00:00 [revised]
PHST- 2011/11/16 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - S0954-6111(11)00400-8 [pii]
AID - 10.1016/j.rmed.2011.11.013 [doi]
PST - ppublish
SO  - Respir Med. 2012 May;106(5):677-86. doi: 10.1016/j.rmed.2011.11.013. Epub 2011 
      Dec 5.