PMID- 22154580
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20131121
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 12
IP  - 1
DP  - 2012 Jan
TI  - Risperidone modulates the cytokine and chemokine release of dendritic cells and 
      induces TNF-alpha-directed cell apoptosis in neutrophils.
PG  - 197-204
LID - 10.1016/j.intimp.2011.11.011 [doi]
AB  - Antipsychotic drugs (APDs) that bind mainly to the dopamine D2 receptor or the 
      type II 5-HT receptor have been used to ease the symptoms of schizophrenia. 
      Several studies have reported that APDs can also regulate the immune response. 
      Dendritic cells (DCs) are the major antigen-presenting cells in the immune 
      system. DCs can release 5-HT and dopamine to modulate T-cell activation and 
      differentiation. In this study, we use the monocyte-derived DCs to investigate 
      the drug effects of typical APD (haloperidol) and atypical APD (risperidone) on 
      DCs in vitro. Our studies revealed that only risperidone but not haloperidol 
      affected the cytokine and chemokine production of mature DCs. Risperidone 
      increased the production of IL-10 and MDC as well as the proinflammatory 
      cytokines, such as IL-6, IL-8, and TNF-alpha, but decreased the production of IP-10 
      and IL-12. Furthermore, the exposure of DCs to risperidone led to lower IFN-gamma 
      production by T-cells. The results suggested that risperidone can modulate the 
      DCs' immune function by inhibiting the potent Th1 cytokines and increasing the 
      potent Th2 cytokines. In addition, the production of TNF-alpha by risperidone-treated 
      mature DCs will induce the death of neutrophils.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Chen, Mao-Liang
AU  - Chen ML
AD  - Department of Research, Buddhist Tzu Chi General Hospital, Taipei Branch, New 
      Taipei City, Taiwan.
FAU - Tsai, Tzung-Chieh
AU  - Tsai TC
FAU - Wang, Lu-Kai
AU  - Wang LK
FAU - Lin, Yi-Yin
AU  - Lin YY
FAU - Tsai, Ya-Min
AU  - Tsai YM
FAU - Lee, Ming-Cheng
AU  - Lee MC
FAU - Tsai, Fu-Ming
AU  - Tsai FM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111205
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - J6292F8L3D (Haloperidol)
RN  - L6UH7ZF8HC (Risperidone)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*pharmacology
MH  - Apoptosis
MH  - Cell Differentiation/drug effects
MH  - Cytokines/immunology
MH  - Dendritic Cells/*drug effects/immunology
MH  - Dopamine Antagonists/pharmacology
MH  - Haloperidol/pharmacology
MH  - Humans
MH  - Neutrophils/*drug effects/immunology
MH  - Risperidone/*pharmacology
MH  - Serotonin Antagonists/pharmacology
MH  - T-Lymphocytes/cytology/drug effects
MH  - Tumor Necrosis Factor-alpha/immunology
EDAT- 2011/12/14 06:00
MHDA- 2012/05/30 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/08/02 00:00 [received]
PHST- 2011/11/07 00:00 [revised]
PHST- 2011/11/23 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - S1567-5769(11)00451-6 [pii]
AID - 10.1016/j.intimp.2011.11.011 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2012 Jan;12(1):197-204. doi: 10.1016/j.intimp.2011.11.011. 
      Epub 2011 Dec 5.