PMID- 22154725
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20211203
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 73
IP  - 2
DP  - 2012 Feb
TI  - HLA-A, -B, and -DRB1 allelic and haplotypic diversity in a sample of bone marrow 
      volunteer donors from Rio Grande do Sul State, Brazil.
PG  - 180-5
LID - 10.1016/j.humimm.2011.11.009 [doi]
AB  - The HLA A, B, and DRB1 allele, phenotype, and haplotype frequencies were studied 
      in a sample of 5,000 volunteer bone marrow donors registered at the Brazilian 
      Volunteer Bone Marrow Donor Registry. The participants live in the state of Rio 
      Grande do Sul and were classified according to ethnic group (4,428 Caucasians, 
      324 mestizos [mixed race], and 248 blacks). Typing was performed using the 
      polymerase chain reaction sequence-specific oligonucleotide method combined with 
      Luminex technology. Twenty-one HLA-A, 33 HLA-B, and 13 HLA-DRB1 allele groups 
      were identified. The most frequent allele groups for each locus were A*02, B*35, 
      and DRB1*13. The most frequent haplotypes were A*01 B*08 DRB1*03 in Caucasians 
      and mestizos and A*02 B*15 and DRB1*04 in blacks. The allele frequencies were 
      compared with samples from different Brazilian regions. In most comparisons no 
      significant differences were found. The most significant differences were 
      observed in the comparison of the groups of our sample, indicating that human 
      leukocyte antigen (HLA) is a good marker to distinguish among people from 
      different ethnic groups. The data provide insight on the knowledge of HLA 
      diversity in the population of Rio Grande do Sul and in the search for a better 
      match for transplant.
CI  - Copyright (c) 2012 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Bortolotto, Andrea Silveira
AU  - Bortolotto AS
AD  - Laboratorio de Imunologia Celular e Molecular, Instituto de Pesquisas Biomedicas, 
      Pontificia Universidade Catolica do Rio Grande do Sul, CEP 91530-000 Porto Alegre 
      RS, Brazil. andrea-sb@hotmail.com
FAU - Petry, Marcia Gomes
AU  - Petry MG
FAU - da Silveira, Janaina Gomes
AU  - da Silveira JG
FAU - Raya, Ana Rosa da Fonte
AU  - Raya AR
FAU - Fernandes, Sandra Regina
AU  - Fernandes SR
FAU - Neumann, Jorge
AU  - Neumann J
FAU - Bonorino, Cristina
AU  - Bonorino C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111128
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Biomarkers)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Biomarkers
MH  - *Bone Marrow
MH  - Brazil/ethnology
MH  - Ethnicity/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-A Antigens/blood/*genetics
MH  - HLA-B Antigens/blood/*genetics
MH  - HLA-DRB1 Chains/blood/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Tissue Donors/statistics & numerical data
EDAT- 2011/12/14 06:00
MHDA- 2012/08/14 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/01/18 00:00 [received]
PHST- 2011/10/13 00:00 [revised]
PHST- 2011/11/07 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - S0198-8859(11)00582-9 [pii]
AID - 10.1016/j.humimm.2011.11.009 [doi]
PST - ppublish
SO  - Hum Immunol. 2012 Feb;73(2):180-5. doi: 10.1016/j.humimm.2011.11.009. Epub 2011 
      Nov 28.